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License agreements (Additional Information) (Detail) - USD ($) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Feb. 10, 2022 | Dec. 31, 2024 | Dec. 31, 2023
License Agreement [Line Items] |  |  |
Common stock, issued |  | 14,856,309 | 1,407,753
Research And Development Expense |  | $ 41,364 | $ 36,966
Harvard Agreement [Member] |  |  |
License Agreement [Line Items] |  |  |
Common stock, issued | 227,486 |  |
License Agreements Payments Description |  | (1) annual maintenance fees ranging from the low five digits to the low six digits during the term of the License Agreement (through the first commercial sale of a royalty-bearing product); (2) royalty payments as a percentage in the low single digits of the annual net sales that the Company generates from products that utilize the license technology (“Licensed Products”) and royalty payments as a percentage in the low single digits of the annual net sales that the Company generates from know-how enabled product licenses (“Know-How Enabled Products”) and (3) a percentage between 10-20% of all non-royalty income received by the Company under sublicenses, strategic partnerships and know-how enabled product licenses that utilize the license technology |
Stock Issued During Period Value | $ 400 |  |
Research And Development Expense |  | $ 400 | 200
Amount Due to Related Party |  | $ 0 | $ 0
One-time license fee | $ 170,000 |  |

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