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Nature of Business - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Jun. 20, 2024
Jan. 30, 2024
Feb. 28, 2025
Dec. 31, 2024
Dec. 31, 2023
Nature Of Operations [Line Items]          
Retained earnings (accumulated deficit)       $ 148,586 $ 90,604
Net Loss       57,982 42,823
Proceeds received pursuant to agreement     $ 185,000    
Cash and cash equivalents       $ 141,239 $ 28,769
Avorbio Common Stock [Member]          
Nature Of Operations [Line Items]          
Stock issued during the period shares new issues converted pursuant to reverse recapitalization       4,163,606  
AVRO Avrobio Common Stock [Member]          
Nature Of Operations [Line Items]          
Reverse stock split       1-for-12  
Conversion of stock shares percentage       0.53%  
Stock issued during the period shares reverse recapitalization       10,956,614  
Stock shares issued during the period subject to reverse recapitalization       11,447  
Subscription Agreement [Member]          
Nature Of Operations [Line Items]          
Stock issued during the period shares new issues   7,790,889      
Sale of stock issue price per share $ 12.4 $ 12.4      
Proceeds from the issuance of common stock $ 96,600 $ 96,600      
Subscription Agreement [Member] | Avorbio Common Stock [Member]          
Nature Of Operations [Line Items]          
Stock issued during the period shares new issues converted pursuant to reverse recapitalization       4,163,606