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Equity Incentive Plans - Summary of the Stock Option Activity (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Options assumed from AVROBIO upon Merger closing 365,428  
Options Exercised, Number of Shares (52,833)  
Options Forfeited and expired, Number of Shares (220,115)  
Closing Balance, Number of shares 92,480  
Options vested and exercisable, Number of Shares 92,480  
Options vested and expected to vest as of December 31, 2024 92,480  
Options Exercised, Weighted- Average Exercise Price $ 14.61  
Options Forfeited and expired, Weighted- Average Exercise Price 136.24  
Options assumed from AVROBIO upon Merger closing 89.92  
Closing Balance, Weighted- Average Exercise Price 22.69  
Options vested and exercisable, Weighted- Average Exercise Price 22.69  
Options vested and expected to vest, Weighted- Average Exercise Price $ 22.69  
Weighted-Average Remaining Contractual Term (Years) 1 year 1 month 6 days  
Options vested and exercisable, Weighted-Average Remaining Contractual Term (Years) 1 year 1 month 6 days  
Weighted-Average Remaining Contractual Term (Years) Unvested and expected to vest as of December 31, 2024 1 year 1 month 6 days  
Options Exercised, Aggregate Intrinsic Value $ 1,344  
Ending Balance, Aggregate Intrinsic Value 2,903  
Options vested and exercisable, Aggregate Intrinsic Value 2,903  
Aggregate Intrinsic Value, Unvested and expected to vest as of December 31, 2024 $ 2,903  
2019 and 2024 [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Outstanding as of January 1, 2024   1,002,485
Options Granted, Number of Shares 982,980  
Options Exercised, Number of Shares (335,894)  
Options Forfeited and expired, Number of Shares (115,210)  
Closing Balance, Number of shares 1,534,361  
Options vested and exercisable, Number of Shares 364,472  
Options vested and expected to vest as of December 31, 2024 1,534,361  
Opening Balance, Weighted- Average Exercise Price   $ 3.11
Options Granted, Weighted- Average Exercise Price $ 18.25  
Options Exercised, Weighted- Average Exercise Price 2.54  
Options Forfeited and expired, Weighted- Average Exercise Price 8.98  
Closing Balance, Weighted- Average Exercise Price 12.49  
Options vested and exercisable, Weighted- Average Exercise Price 2.8  
Options vested and expected to vest, Weighted- Average Exercise Price $ 12.49  
Weighted-Average Remaining Contractual Term (Years) 8 years 6 months 8 years 2 months 12 days
Options vested and exercisable, Weighted-Average Remaining Contractual Term (Years) 6 years 7 months 6 days  
Weighted-Average Remaining Contractual Term (Years) Unvested and expected to vest as of December 31, 2024 8 years 6 months  
Opening Balance, Aggregate Intrinsic Value   $ 2,276
Options Exercised, Aggregate Intrinsic Value $ 5,585  
Ending Balance, Aggregate Intrinsic Value 51,805  
Options vested and exercisable, Aggregate Intrinsic Value 15,809  
Aggregate Intrinsic Value, Unvested and expected to vest as of December 31, 2024 $ 51,805