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License agreements (Additional Information) (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Feb. 10, 2022
Dec. 31, 2024
Dec. 31, 2023
License Agreement [Line Items]      
Common stock, issued   14,856,309 1,407,753
Research And Development Expense   $ 41,364 $ 36,966
Harvard Agreement [Member]      
License Agreement [Line Items]      
Common stock, issued 227,486    
License Agreements Payments Description   (1) annual maintenance fees ranging from the low five digits to the low six digits during the term of the License Agreement (through the first commercial sale of a royalty-bearing product); (2) royalty payments as a percentage in the low single digits of the annual net sales that the Company generates from products that utilize the license technology (“Licensed Products”) and royalty payments as a percentage in the low single digits of the annual net sales that the Company generates from know-how enabled product licenses (“Know-How Enabled Products”) and (3) a percentage between 10-20% of all non-royalty income received by the Company under sublicenses, strategic partnerships and know-how enabled product licenses that utilize the license technology  
Stock Issued During Period Value $ 400    
Research And Development Expense   $ 400 200
Amount Due to Related Party   $ 0 $ 0
One-time license fee $ 170,000