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Segment Information - Schedule of segment net loss and significant segment expenses (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Segment Reporting Information [Line Items]    
Net loss $ (57,982) $ (42,823)
Operating Segments [Member]    
Segment Reporting Information [Line Items]    
Non-controllable expenses 8,733 3,988
Other income 5,134 774
Net loss 57,982 42,823
Operating Segments [Member] | Research and Development Expense [Member]    
Segment Reporting Information [Line Items]    
Total employee-related expenses 11,135 10,351
Operating Segments [Member] | General and Administrative Expense [Member]    
Segment Reporting Information [Line Items]    
Total employee-related expenses 5,553 3,240
Operating Segments [Member] | Research and Pre-clinical Expenses [Member]    
Segment Reporting Information [Line Items]    
Total external research and development expenses 8,477 8,321
Operating Segments [Member] | Clinical and Development Expenses [Member]    
Segment Reporting Information [Line Items]    
Total external research and development expenses 15,380 7,202
Operating Segments [Member] | Chemistry, Manufacturing, and Control Expenses [Member]    
Segment Reporting Information [Line Items]    
Total external research and development expenses $ 3,570 $ 8,947