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Summary Of Significant Accounting Policies - Financial statements (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |
Collaboration and other research and development revenues | $ 14,519 |  | $ 25,818 |  |
Revenue type | us-gaap:ServiceMember |  | us-gaap:ServiceMember |  |
Operating loss | $ (16,258) | $ (26,749) | $ (87,474) | $ (83,491) |
Net loss attributable to common stockholders | $ (15,238) | $ (26,599) | $ (84,899) | $ (84,135) |
Net loss per share attributable to common stockholders, basic and diluted | $ (0.32) | $ (0.64) | $ (1.81) | $ (2.13) |
Deferred revenue, current | $ 8,725 |  | $ 8,725 |  | $ 13,238
Deferred revenue, net of current portion | 104,100 |  | 104,100 |  | 94,725
Accumulated deficit | (391,223) |  | (391,223) |  | $ (305,850)
As originally reported under Topic 606 | ASU 2014-09 |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |
Collaboration and other research and development revenues | 18,974 |  | 28,933 |  |
Operating loss | (11,803) |  | (84,359) |  |
Net loss attributable to common stockholders | $ (10,783) |  | $ (81,784) |  |
Net loss per share attributable to common stockholders, basic and diluted | $ (0.23) |  | $ (1.75) |  |
Deferred revenue, current | $ 13,374 |  | $ 13,374 |  |
Deferred revenue, net of current portion | 86,085 |  | 86,085 |  |
Accumulated deficit | (388,108) |  | (388,108) |  |
Effect of Change | ASU 2014-09 |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |
Collaboration and other research and development revenues | (4,455) |  | (3,115) |  |
Operating loss | (4,455) |  | (3,115) |  |
Net loss attributable to common stockholders | $ (4,455) |  | $ (3,115) |  |
Net loss per share attributable to common stockholders, basic and diluted | $ (0.09) |  | $ (0.07) |  |
Deferred revenue, current | $ (4,649) |  | $ (4,649) |  |
Deferred revenue, net of current portion | 18,015 |  | 18,015 |  |
Accumulated deficit | $ (3,115) |  | $ (3,115) |  |

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