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v3.10.0.1

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Cash flow from operating activities |  |
Net loss | $ (84,899) | $ (84,135)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |
Stock-based compensation expense | 20,251 | 15,287
Depreciation | 2,374 | 1,966
Non-cash research and development expense | 14,442 | 5,000
Non-cash investment in equity securities | (3,667) |
Other non-cash items, net | (2,129) | (17)
Changes in operating assets and liabilities: |  |
Accounts receivable | 636 | (607)
Prepaid expenses and other current assets | (2,349) | (258)
Other non-current assets | (92) | 2
Accounts payable | 1,667 | 2,563
Accrued expenses | 2,344 | (8,962)
Deferred revenue | 4,388 | 84,834
Other current and non-current liabilities |  | (21)
Net cash (used in) provided by operating activities | (47,034) | 15,652
Cash flow from investing activities |  |
Purchases of property and equipment | (3,339) | (1,770)
Proceeds from the sale of equipment | 18 | 15
Purchases of marketable securities | (351,162) | (298,233)
Proceeds from maturities of marketable securities | 310,000 | 89,500
Net cash used in investing activities | (44,483) | (210,488)
Cash flow from financing activities |  |
Proceeds from offering of common stock, net of issuance costs | 48,471 | 96,685
Payments of notes payables |  | (600)
Proceeds from exercise of stock options | 8,376 | 535
Issuances of common stock under benefit plans | 362 |
Payments on construction financing lease obligation | (621) | (565)
Net cash provided by financing activities | 56,588 | 96,055
Net decrease in cash and cash equivalents | (34,929) | (98,781)
Cash, cash equivalents and restricted cash, beginning of period | 148,249 | 186,942
Cash, cash equivalents and restricted cash, end of period | 113,320 | 88,161
Supplemental disclosure of cash and non-cash activities: |  |
Fixed asset additions included in accounts payable and accrued expenses | 676 | 234
Reclassification of liability for common stock subject to repurchase | 4 | 9
Issuance of common stock for settlement of success payments (see note 7) | 9,530 |
Issuance of common stock for asset acquisition | 1,942 |
Issuance of common stock for settlement of notes payable (see note 7) | 12,500 | $ 14,823
Offering costs included in accounts payable and accrued expenses | $ 22 |

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