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Summary Of Significant Accounting Policies - Financial statements (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]          
Collaboration and other research and development revenues $ 14,519   $ 25,818    
Revenue type us-gaap:ServiceMember   us-gaap:ServiceMember    
Operating loss $ (16,258) $ (26,749) $ (87,474) $ (83,491)  
Net loss attributable to common stockholders $ (15,238) $ (26,599) $ (84,899) $ (84,135)  
Net loss per share attributable to common stockholders, basic and diluted $ (0.32) $ (0.64) $ (1.81) $ (2.13)  
Deferred revenue, current $ 8,725   $ 8,725   $ 13,238
Deferred revenue, net of current portion 104,100   104,100   94,725
Accumulated deficit (391,223)   (391,223)   $ (305,850)
As originally reported under Topic 606 | ASU 2014-09          
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]          
Collaboration and other research and development revenues 18,974   28,933    
Operating loss (11,803)   (84,359)    
Net loss attributable to common stockholders $ (10,783)   $ (81,784)    
Net loss per share attributable to common stockholders, basic and diluted $ (0.23)   $ (1.75)    
Deferred revenue, current $ 13,374   $ 13,374    
Deferred revenue, net of current portion 86,085   86,085    
Accumulated deficit (388,108)   (388,108)    
Effect of Change | ASU 2014-09          
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]          
Collaboration and other research and development revenues (4,455)   (3,115)    
Operating loss (4,455)   (3,115)    
Net loss attributable to common stockholders $ (4,455)   $ (3,115)    
Net loss per share attributable to common stockholders, basic and diluted $ (0.09)   $ (0.07)    
Deferred revenue, current $ (4,649)   $ (4,649)    
Deferred revenue, net of current portion 18,015   18,015    
Accumulated deficit $ (3,115)   $ (3,115)