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Condensed Consolidated Statements of Operations - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Condensed Consolidated Statements of Operations        
Collaboration and other research and development revenues $ 14,519 $ 6,282 $ 25,818 $ 10,061
Revenue type us-gaap:ServiceMember   us-gaap:ServiceMember  
Operating expenses:        
Research and development $ 17,443 20,396 $ 71,460 56,735
General and administrative 13,334 12,635 41,832 36,817
Total operating expenses 30,777 33,031 113,292 93,552
Operating loss (16,258) (26,749) (87,474) (83,491)
Other income (expense), net:        
Other (expense) income, net (4) 196 332 458
Interest income (expense), net 1,024 (46) 2,243 (1,102)
Total other income (expense), net 1,020 150 2,575 (644)
Net loss $ (15,238) $ (26,599) $ (84,899) $ (84,135)
Net loss per share attributable to common stockholders, basic and diluted $ (0.32) $ (0.64) $ (1.81) $ (2.13)
Weighted-average common shares outstanding, basic and diluted 47,414,271 41,307,092 46,791,322 39,558,553