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Significant Agreements - Other Agreements (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Aug. 31, 2016
USD ($)
item
Oct. 31, 2014
USD ($)
shares
Aug. 31, 2014
USD ($)
shares
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2017
USD ($)
Notes payable                 $ 7,500
Research and development       $ 17,443 $ 20,396 $ 71,460 $ 56,735    
The General Hospital (MGH) | License Patent Rights                  
Upfront fee     $ 100            
Stock issued to licensors | shares     66,848            
Percentage of outstanding shares issued     0.50%            
Research and development $ 800                
Market capitalization threshold 1,000,000                
Market capitalization                 1,000,000
The General Hospital (MGH) | Maximum | License Patent Rights                  
Potential liability for future clinical, regulatory and commercial milestone payments related to product approval 1,000   $ 3,700            
Potential liability for future sales milestone payments     $ 1,800            
Potential liability for future clinical and regulatory milestone payments related to product approval $ 4,900                
Percentage of net sales threshold for potential milestone payments to be made 1.00%                
Number of licensed products | item 4                
Success Payments $ 6,000                
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | License Patent Rights                  
Upfront fee   $ 200              
Stock issued to licensors | shares   561,531              
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Cpf1 License Agreement                  
Research and development               $ 16,500  
License Agreement Contract Termination Term           4 months      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Cpf1 Market Cap Success Payments                  
Notes payable payment terms           150 days      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Cas9-II License Agreement                  
Market capitalization                 $ 1,000,000
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Maximum | Cpf1 License Agreement                  
Royalties credit paid to third party (as a percent)           50.00%      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Maximum | Cpf1 Success Payments                  
Success Payments           $ 10,000,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Maximum | Cpf1 Market Cap Success Payments                  
Success Payments           125,000      
Market capitalization threshold       10,000,000   10,000,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Maximum | Cas9-II License Agreement                  
Success Payments           30,000      
Market capitalization threshold       9,000,000   9,000,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Minimum | Cpf1 Success Payments                  
Success Payments           750,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Minimum | Cas9-II License Agreement                  
Market capitalization threshold       1,000,000   1,000,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Rare disease | Maximum                  
Potential liability for future sales milestone payments   $ 36,000              
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | Rare disease | Maximum | Cpf1 License Agreement                  
Potential liability for future sales milestone payments       36,000   36,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | United States Europe And Japan | Maximum | License Patent Rights                  
Potential liability for future clinical and regulatory milestone payments related to product approval   14,800              
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | United States Europe And Japan | Human disease | Maximum | Cpf1 License Agreement                  
Potential liability for future clinical and regulatory milestone payments related to product approval       20,000   20,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | United States Europe And Japan | Human disease | Maximum | Cas9-II License Agreement                  
Potential liability for future sales milestone payments       13,500   13,500      
Potential liability for future clinical and regulatory milestone payments related to product approval               $ 3,700  
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | United States Europe And Japan | Rare disease | Maximum | Cpf1 License Agreement                  
Potential liability for future clinical and regulatory milestone payments related to product approval       6,000   6,000      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | United States Europe And Japan | Rare disease | Maximum | Cas9-II License Agreement                  
Potential liability for future sales milestone payments       9,000   9,000      
Potential liability for future clinical and regulatory milestone payments related to product approval       $ 1,100   $ 1,100      
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | United States and one other | Human disease | Maximum | License Patent Rights                  
Potential liability for future clinical and regulatory milestone payments related to product approval   4,100              
Broad, Massachusetts Institute of Technology, or MIT, and Harvard (Institutions) | UNITED STATES | Human disease | Maximum | License Patent Rights                  
Potential liability for future sales milestone payments   $ 54,000