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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Cash flow from operating activities    
Net loss $ (84,899) $ (84,135)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:    
Stock-based compensation expense 20,251 15,287
Depreciation 2,374 1,966
Non-cash research and development expense 14,442 5,000
Non-cash investment in equity securities (3,667)  
Other non-cash items, net (2,129) (17)
Changes in operating assets and liabilities:    
Accounts receivable 636 (607)
Prepaid expenses and other current assets (2,349) (258)
Other non-current assets (92) 2
Accounts payable 1,667 2,563
Accrued expenses 2,344 (8,962)
Deferred revenue 4,388 84,834
Other current and non-current liabilities   (21)
Net cash (used in) provided by operating activities (47,034) 15,652
Cash flow from investing activities    
Purchases of property and equipment (3,339) (1,770)
Proceeds from the sale of equipment 18 15
Purchases of marketable securities (351,162) (298,233)
Proceeds from maturities of marketable securities 310,000 89,500
Net cash used in investing activities (44,483) (210,488)
Cash flow from financing activities    
Proceeds from offering of common stock, net of issuance costs 48,471 96,685
Payments of notes payables   (600)
Proceeds from exercise of stock options 8,376 535
Issuances of common stock under benefit plans 362  
Payments on construction financing lease obligation (621) (565)
Net cash provided by financing activities 56,588 96,055
Net decrease in cash and cash equivalents (34,929) (98,781)
Cash, cash equivalents and restricted cash, beginning of period 148,249 186,942
Cash, cash equivalents and restricted cash, end of period 113,320 88,161
Supplemental disclosure of cash and non-cash activities:    
Fixed asset additions included in accounts payable and accrued expenses 676 234
Reclassification of liability for common stock subject to repurchase 4 9
Issuance of common stock for settlement of success payments (see note 7) 9,530  
Issuance of common stock for asset acquisition 1,942  
Issuance of common stock for settlement of notes payable (see note 7) 12,500 $ 14,823
Offering costs included in accounts payable and accrued expenses $ 22