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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flow from operating activities |  |  |
Net loss | $ (115,976) | $ (133,746) | $ (109,954)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation expense | 23,156 | 27,243 | 26,598
Depreciation | 3,959 | 2,830 | 3,254
Realized gain on corporate equity securities | (16,366) |  |
Non-cash investment in equity securities |  |  | (3,667)
Other non-cash items, net | 104 | (2,928) | (3,268)
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (5,630) | (388) | 649
Prepaid expenses and other current assets | (4,643) | (495) | (3,410)
Right-of-use assets | 3,633 | (9,300) |
Other non-current assets | (719) | (15) | (92)
Accounts payable | 855 | 274 | 1,780
Accrued expenses | 1,707 | 9,485 | 4,042
Deferred revenue | (91,794) | 55,395 | 22,889
Operating lease liabilities | (2,946) | 9,324 |
Other current and non-current liabilities | (2,683) | 1,652 | 1,030
Non-cash research and development expenses | 27,500 |  | 14,442
Net cash used in operating activities | (179,843) | (40,669) | (45,707)
Cash flow from investing activities |  |  |
Purchases of property and equipment | (7,162) | (6,167) | (4,754)
Proceeds from the sale of equipment | 12 | 102 | 37
Purchases of marketable securities | (458,404) | (342,183) | (459,370)
Proceeds from maturities of marketable securities | 305,000 | 360,500 | 411,000
Proceeds from sale of corporate equity securities | 20,032 |  |
Net cash (used in) provided by investing activities | (140,522) | 12,252 | (53,087)
Cash flow from financing activities |  |  |
Proceeds from offering of common stock, net of issuance costs | 203,726 | 116,341 | 76,789
Proceeds from exercise of stock options | 19,501 | 14,863 | 10,328
Payments on construction financing lease obligation |  |  | (857)
Issuance of common stock under benefit plans | 895 | 620 | 680
Net cash provided by financing activities | 224,122 | 131,824 | 86,940
Net increase (decrease) in cash, cash equivalents, and restricted cash | (96,243) | 103,407 | (11,854)
Cash, cash equivalents, and restricted cash, beginning of period | 239,802 | 136,395 | 148,249
Cash, cash equivalents, and restricted cash, end of period | 143,559 | 239,802 | 136,395
Supplemental disclosure of cash and non-cash activities: |  |  |
Fixed asset additions included in accounts payable and accrued expenses | 656 | 728 | 659
Cash paid in connection with operating lease liabilities | $ 9,760 | 5,970 |
Offering costs included in accounts payable and accrued expenses |  | 15 | 92
Right-of-use assets obtained in exchange of operating lease obligations |  | $ 19,461 |
Reclassification of liability for common stock subject to repurchase |  |  | 4
Issuance of common stock for repayment of notes payable |  |  | 22,030
Issuance of common stock for asset acquisition |  |  | $ 1,942

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