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Stock-based Compensation
3 Months Ended
Mar. 31, 2022
Stock-based Compensation  
Stock-based Compensation

9. Stock-based Compensation

Total compensation cost recognized for all stock-based compensation awards in the condensed consolidated statements of operations was as follows (in thousands):

    

    

Three Months Ended

March 31, 

2022

2021

Research and development

$

3,695

$

3,966

General and administrative

 

7,736

 

8,238

Total stock-based compensation expense

$

11,431

$

12,204

Restricted Stock and Restricted Stock Unit Awards

The following is a summary of restricted stock and restricted stock unit awards activity for the three months ended March 31, 2022:

    

    

Weighted

Average

Grant Date

Fair Value

Shares

Per Share

Unvested restricted stock and restricted stock unit awards as of December 31, 2021

 

628,732

$

41.28

Issued

 

815,627

$

17.30

Vested

 

(154,834)

$

52.88

Forfeited

(56,307)

$

33.23

Unvested restricted stock and restricted stock unit awards as of March 31, 2022

 

1,233,218

$

24.33

The restricted stock and restricted stock units granted in the three months ended March 31, 2022 include 259,367 units granted to certain employees that contain performance-based vesting provisions. The Company recognizes the fair value of the performance-based units through the expected achievement date if the performance-based vesting provisions are deemed probable.

As of March 31, 2022, total unrecognized compensation expense related to unvested restricted stock and restricted stock unit awards was $19.1 million, which the Company expects to recognize over a remaining weighted-average period of 2.9 years.

Stock Options

The following is a summary of stock option activity for the three months ended March 31, 2022:

    

    

Weighted Average

    

Remaining

    

Aggregate Intrinsic

Shares

Exercise Price

Contractual Life (years)

Value (in thousands)

Outstanding at December 31, 2021

 

3,016,085

$

34.24

7.5

$

5,052,469

Granted

1,136,614

$

17.29

Exercised

(12,573)

$

17.31

Cancelled

(220,043)

$

30.30

Outstanding at March 31, 2022

 

3,920,083

$

29.60

7.9

$

3,954,769

Exercisable at March 31, 2022

 

1,483,822

$

29.34

6.5

$

2,023,433

As of March 31, 2022, total unrecognized compensation expense related to stock options was $34.4 million, which the Company expects to recognize over a remaining weighted-average period of 3.1 years.