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Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2022

Stock-based Compensation

Schedule of stock-based compensation expense

Total compensation cost recognized for all stock-based compensation awards in the condensed consolidated statements of operations was as follows (in thousands):

​	​	​	​	​	​	​
​		​	​		​	​
​	​	​	​	​	​	​
​	​	Three Months Ended
​	​	March 31,
​	​	2022		​	2021
Research and development	​	$	3,695	​	$	3,966
General and administrative	​		7,736	​		8,238
Total stock-based compensation expense	​	$	11,431	​	$	12,204

Schedule of changes in unvested restricted stock

The following is a summary of restricted stock and restricted stock unit awards activity for the three months ended March 31, 2022:

​	​	​	​	​	​
​		​		Weighted
​	​	​	​	Average
​	​	​	​	Grant Date
​	​	​	​	Fair Value
​	​	Shares	​	Per Share
Unvested restricted stock and restricted stock unit awards as of December 31, 2021		628,732	​	$	41.28
Issued		815,627	​	$	17.30
Vested		(154,834)	​	$	52.88
Forfeited	​	(56,307)	​	$	33.23
Unvested restricted stock and restricted stock unit awards as of March 31, 2022		1,233,218	​	$	24.33

Schedule of stock option activity

The following is a summary of stock option activity for the three months ended March 31, 2022:

​

​	​	​	​	​	​	​	​	​	​	​
​		​		Weighted Average			Remaining		Aggregate Intrinsic
​	​	Shares	​	Exercise Price		​	Contractual Life (years)	​	Value (in thousands)
Outstanding at December 31, 2021		3,016,085	​	$	34.24	​	7.5	​	$	5,052,469
Granted	​	1,136,614	​	$	17.29	​	​	​	​	​
Exercised	​	(12,573)	​	$	17.31	​	​	​	​	​
Cancelled	​	(220,043)	​	$	30.30	​	​	​	​	​
Outstanding at March 31, 2022		3,920,083	​	$	29.60	​	7.9	​	$	3,954,769
Exercisable at March 31, 2022		1,483,822	​	$	29.34	​	6.5	​	$	2,023,433

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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