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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flow from operating activities    
Net loss $ (50,515) $ (56,728)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 11,431 12,204
Depreciation 1,558 1,163
Other non-cash items, net 234 401
Changes in operating assets and liabilities:    
Accounts receivable (1,105) 5,376
Prepaid expenses and other current assets (99) 4,618
Right-of-use assets 2,716 (4,177)
Other non-current assets (505) (1,985)
Accounts payable (229) 2,017
Accrued expenses (3,982) (9,563)
Deferred revenue (5,516) (5,555)
Operating lease liabilities (3,215) 2,750
Net cash used in operating activities (49,227) (49,479)
Cash flow from investing activities    
Purchases of property and equipment (2,248) (84)
Purchases of marketable securities (60,381) (127,422)
Proceeds from maturities of marketable securities 119,000 130,750
Net cash provided by investing activities 56,371 3,244
Cash flow from financing activities    
Proceeds from offering of common stock, net of issuance costs   249,469
Proceeds from exercise of stock options 218 12,002
Net cash provided by financing activities 218 261,471
Net increase in cash, cash equivalents, and restricted cash 7,362 215,236
Cash, cash equivalents, and restricted cash, beginning of period 207,396 143,559
Cash, cash equivalents, and restricted cash, end of period 214,758 358,795
Supplemental disclosure of cash and non-cash activities:    
Fixed asset additions included in accounts payable and accrued expenses 199 467
Cash paid in connection with operating lease liabilities $ 3,746 4,248
Offering costs included in accounts payable and accrued expenses   $ 10