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Stock-based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2022
Stock-based Compensation |
Schedule of stock-based compensation expense | Total compensation cost recognized for all stock-based compensation awards in the condensed consolidated statements of operations was as follows (in thousands):
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three Months Ended | ​ | Nine Months Ended
​ | ​ | September 30, | ​ | September 30,
​ | ​ | 2022 | ​ | 2021 | ​ | 2022 | ​ | 2021
Research and development | ​ | $ | 3,045 | ​ | $ | 4,552 | ​ | $ | 9,803 | ​ | $ | 12,689
General and administrative | ​ |  | 2,836 | ​ |  | 5,460 | ​ |  | 14,127 | ​ |  | 23,053
Total stock-based compensation expense | ​ | $ | 5,881 | ​ | $ | 10,012 | ​ | $ | 23,930 | ​ | $ | 35,742
Schedule of changes in unvested restricted stock | The following is a summary of restricted stock and restricted stock unit awards activity for the nine months ended September 30, 2022:
​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | Weighted
​ | ​ | ​ | ​ | Average
​ | ​ | ​ | ​ | Grant Date
​ | ​ | ​ | ​ | Fair Value
​ | ​ | Shares | ​ | Per Share
Unvested restricted stock and restricted stock unit awards as of December 31, 2021 |  | 628,732 | ​ | $ | 41.28
Issued |  | 1,334,826 | ​ | $ | 15.57
Vested |  | (271,037) | ​ | $ | 44.69
Forfeited | ​ | (188,839) | ​ | $ | 31.88
Unvested restricted stock and restricted stock unit awards as of September 30, 2022 |  | 1,503,682 | ​ | $ | 19.02
Schedule of stock option activity | The following is a summary of stock option activity for the nine months ended September 30, 2022: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | Weighted Average |  | Remaining |  | Aggregate Intrinsic
​ | ​ | Shares | ​ | Exercise Price | ​ | Contractual Life (years) | ​ | Value (in thousands)
Outstanding at December 31, 2021 |  | 3,016,085 | ​ | $ | 34.24 | ​ | 7.5 | ​ | $ | 5,052,469
Granted | ​ | 2,749,534 | ​ | $ | 14.64 | ​ | ​ | ​ | ​ | ​
Exercised | ​ | (17,569) | ​ | $ | 16.97 | ​ | ​ | ​ | ​ | ​
Cancelled | ​ | (531,926) | ​ | $ | 30.78 | ​ | ​ | ​ | ​ | ​
Outstanding at September 30, 2022 |  | 5,216,124 | ​ | $ | 24.32 | ​ | 8.2 | ​ | $ | 1,534,373
Exercisable at September 30, 2022 |  | 1,906,975 | ​ | $ | 30.80 | ​ | 6.8 | ​ | $ | 807,066

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