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Stock-based Compensation (Tables)

9 Months Ended

Sep. 30, 2023

Share-Based Payment Arrangement [Abstract]

Schedule of Stock-Based Compensation Expense

Total compensation cost recognized for all stock-based compensation awards in the condensed consolidated statements of operations was as follows (in thousands):

			Three Months Ended September 30,												Nine Months Ended September 30,
			2023						2022						2023						2022
Research and development			$	2,571					$	3,045					$	7,182					$	9,803
General and administrative			2,160						2,836						7,271						14,127
Total stock-based compensation expense			$	4,731					$	5,881					$	14,453					$	23,930

Schedule of Changes in Unvested Restricted Stock

The following is a summary of restricted stock unit awards activity for the nine months ended September 30, 2023:

			Shares						Weighted Average Grant Date Fair Value Per Share
Unvested restricted stock unit awards as of December 31, 2022			1,499,070						$	18.70
Issued			1,331,578						$	8.71
Vested			(262,588)						$	19.87
Forfeited			(462,777)						$	18.86
Unvested restricted stock unit awards as of September 30, 2023			2,105,283						$	12.20

Schedule of Stock Option Activity

The following is a summary of stock option activity for the nine months ended September 30, 2023:

			Shares						Weighted Average Exercise Price						Remaining Contractual Life (years)						Aggregate Intrinsic Value
Outstanding at December 31, 2022			5,276,148						$	23.99					8.00						$	402
Granted			2,195,300						$	8.74
Exercised			(3,122)						$	3.38
Cancelled			(1,467,700)						$	30.95
Outstanding at September 30, 2023			6,000,626						$	16.72					7.83						$	342
Exercisable at September 30, 2023			2,449,032						$	22.72					6.34						$	279

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Name Accounting Standards Codification
-Section 50
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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