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Segments (Tables) | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Schedule of Segment Reporting Information, by Segment | The following table contains additional information on our consolidated revenue and net loss, including significant segment expenses (in thousands):
| Three Months Ended September 30, |  | Nine Months Ended September 30,
| 2025 |  |  | 2024 |  | 2025 |  |  | 2024
Collaboration and other research and development revenues | $ | 7,543 |  |  |  | $ | 61 |  |  | $ | 15,779 |  |  |  | $ | 1,710 |
Operating expenses: |  |  |  |  |  |  |  |  |
Research and development 1 |  |  |  |  |  |  |  |  |
Employee related expenses | 6,468 |  |  |  | 14,486 |  |  | 29,210 |  |  |  | 41,830 |
External research and development expenses | 6,465 |  |  |  | 20,058 |  |  | 66,930 |  |  |  | 64,670 |
Facility expenses | 3,254 |  |  |  | 7,229 |  |  | 17,228 |  |  |  | 19,818 |
Stock-based compensation expenses | 634 |  |  |  | 2,048 |  |  | 2,404 |  |  |  | 7,081 |
Sublicense and license fees | 1,292 |  |  |  | 307 |  |  | 1,404 |  |  |  | 7,060 |
Other expenses 2 | 1,662 |  |  |  | 3,511 |  |  | 9,447 |  |  |  | 10,177 |
General and administrative 3 |  |  |  |  |  |  |  |  |
Employee related expenses | 2,491 |  |  |  | 5,902 |  |  | 11,033 |  |  |  | 15,594 |
Professional service expenses | 1,902 |  |  |  | 4,121 |  |  | 7,262 |  |  |  | 10,929 |
Intellectual property and patent related fees | 5,279 |  |  |  | 3,291 |  |  | 11,836 |  |  |  | 11,080 |
Stock-based compensation expenses | 1,594 |  |  |  | 2,754 |  |  | 5,467 |  |  |  | 10,316 |
Facility and other expenses 4 | 1,050 |  |  |  | 2,020 |  |  | 5,813 |  |  |  | 7,714 |
Total operating expenses | 32,091 |  |  |  | 65,727 |  |  | 168,034 |  |  |  | 206,269 |
Operating loss | (24,548) |  |  |  | (65,666) |  |  | (152,255) |  |  |  | (204,559) |
Other (expense) income, net: |  |  |  |  |  |  |  |  |
Interest expense related to sale of future revenues | (2,399) |  |  |  | — |  |  | (6,635) |  |  |  | — |
Interest income, net | 1,831 |  |  |  | 3,530 |  |  | 6,634 |  |  |  | 12,861 |
Other expense, net | (1) |  |  |  | (5) |  |  | (2,184) |  |  |  | — |
Total other (expense) income, net | (569) |  |  |  | 3,525 |  |  | (2,185) |  |  |  | 12,861 |
Net loss | $ | (25,117) |  |  |  | $ | (62,141) |  |  | $ | (154,440) |  |  |  | $ | (191,698) |
1 The nine months ended September 30, 2025 include $64,075 of restructuring and impairment charges. The three months ended September 30, 2025 and the three and nine months ended September 30, 2024 include no restructuring and impairment charges, respectively.
2 Other expenses primarily consists of impairment charges, consultant fees and office expenses.
3 The nine months ended September 30, 2025 include $2,860 of restructuring and impairment charges. The three months ended September 30, 2025 and the three and nine months ended September 30, 2024 include no restructuring and impairment charges, respectively.
4 Facility and other expenses primarily consists of rent expense, insurance premiums, depreciation expense, software licenses and office expenses.

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- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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