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Segments - Schedule of Segment Reporting Information, by Segment (Details) - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Segment Reporting Information [Line Items]                
Collaboration and other research and development revenues $ 7,543,000     $ 61,000     $ 15,779,000 $ 1,710,000
Operating expenses:                
Stock-based compensation expenses 2,228,000     4,802,000     7,871,000 17,397,000
Total operating expenses 32,091,000     65,727,000     168,034,000 206,269,000
Operating loss (24,548,000)     (65,666,000)     (152,255,000) (204,559,000)
Other (expense) income, net:                
Interest expense related to sale of future revenues (2,399,000)     0     (6,635,000) 0
Interest income, net 1,831,000     3,530,000     6,634,000 12,861,000
Other expense, net (1,000)     (5,000)     (2,184,000) 0
Total other (expense) income, net (569,000)     3,525,000     (2,185,000) 12,861,000
Net loss (25,117,000) $ (53,235,000) $ (76,088,000) (62,141,000) $ (67,607,000) $ (61,950,000) (154,440,000) (191,698,000)
Reportable Segment                
Segment Reporting Information [Line Items]                
Collaboration and other research and development revenues 7,543,000     61,000     15,779,000 1,710,000
Operating expenses:                
Total operating expenses 32,091,000     65,727,000     168,034,000 206,269,000
Operating loss (24,548,000)     (65,666,000)     (152,255,000) (204,559,000)
Other (expense) income, net:                
Interest income, net 1,831,000     3,530,000     6,634,000 12,861,000
Other expense, net (1,000)     (5,000)     (2,184,000) 0
Total other (expense) income, net (569,000)     3,525,000     (2,185,000) 12,861,000
Net loss (25,117,000)     (62,141,000)     (154,440,000) (191,698,000)
Research and development                
Operating expenses:                
Stock-based compensation expenses 634,000     2,048,000     2,404,000 7,081,000
Research and development | Reportable Segment                
Operating expenses:                
Employee related expenses 6,468,000     14,486,000     29,210,000 41,830,000
External research and development expenses 6,465,000     20,058,000     66,930,000 64,670,000
Facility expenses 3,254,000     7,229,000     17,228,000 19,818,000
Stock-based compensation expenses 634,000     2,048,000     2,404,000 7,081,000
Sublicense and license fees 1,292,000     307,000     1,404,000 7,060,000
Other expenses 1,662,000     3,511,000     9,447,000 10,177,000
Other (expense) income, net:                
Restructuring and impairment charges 0     0     64,075,000 0
General and administrative                
Operating expenses:                
Stock-based compensation expenses 1,594,000     2,754,000     5,467,000 10,316,000
General and administrative | Reportable Segment                
Operating expenses:                
Employee related expenses 2,491,000     5,902,000     11,033,000 15,594,000
Facility expenses 1,050,000     2,020,000     5,813,000 7,714,000
Stock-based compensation expenses 1,594,000     2,754,000     5,467,000 10,316,000
Professional service expenses 1,902,000     4,121,000     7,262,000 10,929,000
Intellectual property and patent related fees 5,279,000     3,291,000     11,836,000 11,080,000
Other (expense) income, net:                
Restructuring and impairment charges $ 0     $ 0     $ 2,860,000 $ 0