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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Pay vs Performance Disclosure |  |  |
Pay vs Performance Disclosure, Table | Pay Versus Performance Disclosure As required by Item 402(v) of Regulation S-K, we are providing the following information regarding the relationship between the executive “compensation actually paid” to our principal executive officer (PEO) and our other named executive officers (NEO) and our financial performance for each of the last three completed fiscal years. In determining the “compensation actually paid” (CAP) to our NEOs, we are required to make various adjustments to amounts that have in prior years been reported in the Summary Compensation Table (SCT), as the SEC valuation methods for this disclosure differ from those required in the SCT. The values do not necessarily represent the actual compensation received by the NEOs nor how the Compensation Committee evaluates and determines executive compensation levels. For our NEOs other than our PEO, compensation is reported as an average.
Year |  | SCT Total for PEO(1) |  |  | CAP to PEO(1)(2)(3) |  |  | Average SCT Total for Non-PEO named executive officers(4) |  |  | Average CAP to Non-PEO named executive officers(2)(3)(4) |  |  | Value of initial fixed $100 investment based on Total Shareholder Return (TSR)(5) |  |  | Net Income (in $000s)(6) |
2024 |  | $ | 3,931,645 |  |  | $ | 6,050,349 |  |  | $ | 1,005,859 |  |  | $ | 949,776 |  |  | $ | 124.75 |  |  | ($ | 55,851 | )
2023 |  | $ | 3,684,651 |  |  | ($ | 1,220,740 | ) |  | $ | 1,283,588 |  |  | $ | 75,336 |  |  | $ | 87.75 |  |  | ($ | 37,543 | )
2022 |  | $ | 2,858,490 |  |  | $ | 10,614,223 |  |  | $ | 2,023,636 |  |  | $ | 3,308,975 |  |  | $ | 174.00 |  |  | ($ | 62,025 | )
(1) | The PEO for all three years included in the table is Todd C. Brady, M.D., Ph.D, our Chief Executive Officer. The dollar amounts reported in this column are the amounts of total compensation reported for Dr. Brady in the “Total” column of the SCT in the applicable fiscal year.
(2) | In accordance with SEC rules, deductions from and additions to, total compensation reported in the SCT by year to calculate Compensation Actually Paid include:
|  | Average Non-PEO named executive officers |
|  | 2024 |  |  | 2023 |  |  | 2022 |  |  | 2024 |  |  | 2023 |  |  | 2022 |
SCT Total |  | $ | 3,931,645 |  |  | $ | 3,684,651 |  |  | $ | 2,858,490 |  |  | $ | 1,005,859 |  |  | $ | 1,283,588 |  |  | $ | 2,023,636 |
Adjustments for Equity Awards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deduct:Grantdate values in SCT |  | -$ | 3,000,817 |  |  | -$ | 2,850,548 |  |  | -$ | 1,948,523 |  |  | -$ | 608,498 |  |  | -$ | 816,863 |  |  | -$ | 1,535,579 |
Add:Year-endfair value of unvested awards granted in the current year |  | $ | 3,050,702 |  |  | $ | 1,302,920 |  |  | $ | 7,938,000 |  |  | $ | 381,337 |  |  | $ | 307,105 |  |  | $ | 2,448,681 |
Add:Year-over-yeardifference of year-end fair values for unvested awards granted in prior years |  | $ | 1,137,053 |  |  | -$ | 3,936,684 |  |  | $ | 1,486,804 |  |  | $ | 139,692 |  |  | -$ | 969,744 |  |  | $ | 179,149 |
Add:Fairvalues at vest date for awards granted and vested in current year |  | $ | 809,973 |  |  | $ | 327,217 |  |  | $ | 196,282 |  |  | $ | 158,427 |  |  | $ | 216,150 |  |  | $ | 166,207 |
Add:Differencein fair values between prior year-end fair values and vest date fair values for awards granted in prior years |  | $ | 121,792 |  |  | $ | 251,703 |  |  | $ | 83,170 |  |  | $ | 42,141 |  |  | $ | 55,100 |  |  | $ | 26,880 |
Deduct:Forfeituresduring current year equal to prior year-end fair value |  | $ | 0 |  |  | $ | 0 |  |  | $ | 0 |  |  | -$ | 169,182 |  |  | $ | 0 |  |  | $ | 0 |
Total Adjustments for Equity Awards |  | $ | 2,118,704 |  |  | -$ | 4,905,391 |  |  | $ | 7,755,733 |  |  | -$ | 56,083 |  |  | -$ | 1,208,252 |  |  | $ | 1,285,339 |
CAP |  | $ | 6,050,349 |  |  | -$ | 1,220,740 |  |  | $ | 10,614,223 |  |  | $ | 949,776 |  |  | $ | 75,336 |  |  | $ | 3,308,975 |
(3) | The following summarizes the valuation assumptions used for stock option awards included as part of CAP:
| • |  | Expected life of each stock option is based on the “simplified method” using an average of the remaining vest and remaining term, as of the vest/fiscal year end (FYE) date.
| • |  | Strike price is based on each grant date closing price and asset price is based on each vest/FYE closing price.
| • |  | Risk free rate is based on the Treasury Constant Maturity rate closest to the remaining expected life as of the vest/FYE date.
| • |  | Historical volatility is based on daily price history for each expected life (years) prior to each vest/FYE date. Closing prices provided by S&P Capital IQ are adjusted for dividends and splits.
| • |  | Represents annual dividend yield on each vest/FYE date.
(4) | Non-PEO named executive officer averages reflect the following executives by year:
| • |  | 2024: Bruce Greenberg, Stephen G. Machatha, and Michael Alfieri
| • |  | 2022 and 2023: Bruce Greenberg, and Stephen G. Machatha
The dollar amounts reported in this column represent the average of the amounts reported for the non-PEO named executive officers in the “Total” column of the SCT in the applicable fiscal year.
(5) | The dollar amounts reported represent the amount of net income (loss) reflected in our audited financial statements for the applicable year.
Named Executive Officers, Footnote |
(4) | Non-PEO named executive officer averages reflect the following executives by year:
| • |  | 2024: Bruce Greenberg, Stephen G. Machatha, and Michael Alfieri
| • |  | 2022 and 2023: Bruce Greenberg, and Stephen G. Machatha
The dollar amounts reported in this column represent the average of the amounts reported for the non-PEO named executive officers in the “Total” column of the SCT in the applicable fiscal year. |  |
PEO Total Compensation Amount | $ 3,931,645 | $ 3,684,651 | $ 2,858,490
PEO Actually Paid Compensation Amount | $ 6,050,349 | (1,220,740) | 10,614,223
Adjustment To PEO Compensation, Footnote |
(2) | In accordance with SEC rules, deductions from and additions to, total compensation reported in the SCT by year to calculate Compensation Actually Paid include:
|  | Average Non-PEO named executive officers |
|  | 2024 |  |  | 2023 |  |  | 2022 |  |  | 2024 |  |  | 2023 |  |  | 2022 |
SCT Total |  | $ | 3,931,645 |  |  | $ | 3,684,651 |  |  | $ | 2,858,490 |  |  | $ | 1,005,859 |  |  | $ | 1,283,588 |  |  | $ | 2,023,636 |
Adjustments for Equity Awards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deduct:Grantdate values in SCT |  | -$ | 3,000,817 |  |  | -$ | 2,850,548 |  |  | -$ | 1,948,523 |  |  | -$ | 608,498 |  |  | -$ | 816,863 |  |  | -$ | 1,535,579 |
Add:Year-endfair value of unvested awards granted in the current year |  | $ | 3,050,702 |  |  | $ | 1,302,920 |  |  | $ | 7,938,000 |  |  | $ | 381,337 |  |  | $ | 307,105 |  |  | $ | 2,448,681 |
Add:Year-over-yeardifference of year-end fair values for unvested awards granted in prior years |  | $ | 1,137,053 |  |  | -$ | 3,936,684 |  |  | $ | 1,486,804 |  |  | $ | 139,692 |  |  | -$ | 969,744 |  |  | $ | 179,149 |
Add:Fairvalues at vest date for awards granted and vested in current year |  | $ | 809,973 |  |  | $ | 327,217 |  |  | $ | 196,282 |  |  | $ | 158,427 |  |  | $ | 216,150 |  |  | $ | 166,207 |
Add:Differencein fair values between prior year-end fair values and vest date fair values for awards granted in prior years |  | $ | 121,792 |  |  | $ | 251,703 |  |  | $ | 83,170 |  |  | $ | 42,141 |  |  | $ | 55,100 |  |  | $ | 26,880 |
Deduct:Forfeituresduring current year equal to prior year-end fair value |  | $ | 0 |  |  | $ | 0 |  |  | $ | 0 |  |  | -$ | 169,182 |  |  | $ | 0 |  |  | $ | 0 |
Total Adjustments for Equity Awards |  | $ | 2,118,704 |  |  | -$ | 4,905,391 |  |  | $ | 7,755,733 |  |  | -$ | 56,083 |  |  | -$ | 1,208,252 |  |  | $ | 1,285,339 |
CAP |  | $ | 6,050,349 |  |  | -$ | 1,220,740 |  |  | $ | 10,614,223 |  |  | $ | 949,776 |  |  | $ | 75,336 |  |  | $ | 3,308,975 |
Non-PEO NEO Average Total Compensation Amount | $ 1,005,859 | 1,283,588 | 2,023,636
Non-PEO NEO Average Compensation Actually Paid Amount | $ 949,776 | 75,336 | 3,308,975
Adjustment to Non-PEO NEO Compensation Footnote |
(2) | In accordance with SEC rules, deductions from and additions to, total compensation reported in the SCT by year to calculate Compensation Actually Paid include:
|  | Average Non-PEO named executive officers |
|  | 2024 |  |  | 2023 |  |  | 2022 |  |  | 2024 |  |  | 2023 |  |  | 2022 |
SCT Total |  | $ | 3,931,645 |  |  | $ | 3,684,651 |  |  | $ | 2,858,490 |  |  | $ | 1,005,859 |  |  | $ | 1,283,588 |  |  | $ | 2,023,636 |
Adjustments for Equity Awards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deduct:Grantdate values in SCT |  | -$ | 3,000,817 |  |  | -$ | 2,850,548 |  |  | -$ | 1,948,523 |  |  | -$ | 608,498 |  |  | -$ | 816,863 |  |  | -$ | 1,535,579 |
Add:Year-endfair value of unvested awards granted in the current year |  | $ | 3,050,702 |  |  | $ | 1,302,920 |  |  | $ | 7,938,000 |  |  | $ | 381,337 |  |  | $ | 307,105 |  |  | $ | 2,448,681 |
Add:Year-over-yeardifference of year-end fair values for unvested awards granted in prior years |  | $ | 1,137,053 |  |  | -$ | 3,936,684 |  |  | $ | 1,486,804 |  |  | $ | 139,692 |  |  | -$ | 969,744 |  |  | $ | 179,149 |
Add:Fairvalues at vest date for awards granted and vested in current year |  | $ | 809,973 |  |  | $ | 327,217 |  |  | $ | 196,282 |  |  | $ | 158,427 |  |  | $ | 216,150 |  |  | $ | 166,207 |
Add:Differencein fair values between prior year-end fair values and vest date fair values for awards granted in prior years |  | $ | 121,792 |  |  | $ | 251,703 |  |  | $ | 83,170 |  |  | $ | 42,141 |  |  | $ | 55,100 |  |  | $ | 26,880 |
Deduct:Forfeituresduring current year equal to prior year-end fair value |  | $ | 0 |  |  | $ | 0 |  |  | $ | 0 |  |  | -$ | 169,182 |  |  | $ | 0 |  |  | $ | 0 |
Total Adjustments for Equity Awards |  | $ | 2,118,704 |  |  | -$ | 4,905,391 |  |  | $ | 7,755,733 |  |  | -$ | 56,083 |  |  | -$ | 1,208,252 |  |  | $ | 1,285,339 |
CAP |  | $ | 6,050,349 |  |  | -$ | 1,220,740 |  |  | $ | 10,614,223 |  |  | $ | 949,776 |  |  | $ | 75,336 |  |  | $ | 3,308,975 |
Compensation Actually Paid vs. Total Shareholder Return | Relationship Between Compensation Actually Paid and Total Shareholder Return The following chart illustrates the relationship between CAP to our PEO and Non-PEO NEOs (averaged), and the TSR over the reporting period. For our NEOs, a significant portion of’ compensation consists of equity awards. As a result, as demonstrated in the chart below, the amount of CAP to our NEOs is aligned with our cumulative TSR over the three-year period presented below. |  |
Compensation Actually Paid vs. Net Income | Relationship Between Compensation Actually Paid and Net Income The following chart illustrates the relationship between CAP to our PEO and Non-PEO NEO (averaged), and the Net Income over the reporting period. The CAP to our PEO and Non-PEO NEOs and Net Income is not correlated over the three years shown below. While we are required by SEC rules to disclose the relationship between our net income and compensation “actually paid” to our NEOs, this is not a metric our compensation committee currently uses in evaluating our NEOs compensation. |  |
Total Shareholder Return Amount | $ 124.75 | 87.75 | 174
Net Income (Loss) | $ (55,851,000) | (37,543,000) | (62,025,000)
PEO Name | Todd C. Brady, M.D., Ph.D |  |
PEO | Equity Awards Adjustments |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ 2,118,704 | (4,905,391) | 7,755,733
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (3,000,817) | (2,850,548) | (1,948,523)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 3,050,702 | 1,302,920 | 7,938,000
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 1,137,053 | (3,936,684) | 1,486,804
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 809,973 | 327,217 | 196,282
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 121,792 | 251,703 | 83,170
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 | 0 | 0
Non-PEO NEO | Equity Awards Adjustments |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (56,083) | (1,208,252) | 1,285,339
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (608,498) | (816,863) | (1,535,579)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 381,337 | 307,105 | 2,448,681
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 139,692 | (969,744) | 179,149
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 158,427 | 216,150 | 166,207
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 42,141 | 55,100 | 26,880
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ (169,182) | $ 0 | $ 0

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