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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

Pay vs Performance Disclosure

Pay vs Performance Disclosure, Table

Pay Versus Performance Disclosure

As required by Item 402(v) of Regulation S-K, we are providing the following information regarding the relationship between the executive “compensation actually paid” to our principal executive officer (PEO) and our other named executive officers (NEO) and our financial performance for each of the last three completed fiscal years. In determining the “compensation actually paid” (CAP) to our NEOs, we are required to make various adjustments to amounts that have in prior years been reported in the Summary Compensation Table (SCT), as the SEC valuation methods for this disclosure differ from those required in the SCT. The values do not necessarily represent the actual compensation received by the NEOs nor how the Compensation Committee evaluates and determines executive compensation levels. For our NEOs other than our PEO, compensation is reported as an average.

Year		SCT Total for PEO(1)				CAP to PEO(1)(2)(3)				Average SCT Total for Non-PEO named executive officers(4)				Average CAP to Non-PEO named executive officers(2)(3)(4)				Value of initial fixed $100 investment based on Total Shareholder Return (TSR)(5)				Net Income (in $000s)(6)
2024		$	3,931,645			$	6,050,349			$	1,005,859			$	949,776			$	124.75			($	55,851	)
2023		$	3,684,651			($	1,220,740	)		$	1,283,588			$	75,336			$	87.75			($	37,543	)
2022		$	2,858,490			$	10,614,223			$	2,023,636			$	3,308,975			$	174.00			($	62,025	)

(1) The PEO for all three years included in the table is Todd C. Brady, M.D., Ph.D, our Chief Executive Officer. The dollar amounts reported in this column are the amounts of total compensation reported for Dr. Brady in the “Total” column of the SCT in the applicable fiscal year.

(2) In accordance with SEC rules, deductions from and additions to, total compensation reported in the SCT by year to calculate Compensation Actually Paid include:

		Average Non-PEO named executive officers
		2024				2023				2022				2024				2023				2022
SCT Total		$	3,931,645			$	3,684,651			$	2,858,490			$	1,005,859			$	1,283,588			$	2,023,636
Adjustments for Equity Awards
Deduct:Grantdate values in SCT		-$	3,000,817			-$	2,850,548			-$	1,948,523			-$	608,498			-$	816,863			-$	1,535,579
Add:Year-endfair value of unvested awards granted in the current year		$	3,050,702			$	1,302,920			$	7,938,000			$	381,337			$	307,105			$	2,448,681
Add:Year-over-yeardifference of year-end fair values for unvested awards granted in prior years		$	1,137,053			-$	3,936,684			$	1,486,804			$	139,692			-$	969,744			$	179,149
Add:Fairvalues at vest date for awards granted and vested in current year		$	809,973			$	327,217			$	196,282			$	158,427			$	216,150			$	166,207
Add:Differencein fair values between prior year-end fair values and vest date fair values for awards granted in prior years		$	121,792			$	251,703			$	83,170			$	42,141			$	55,100			$	26,880
Deduct:Forfeituresduring current year equal to prior year-end fair value		$	0			$	0			$	0			-$	169,182			$	0			$	0
Total Adjustments for Equity Awards		$	2,118,704			-$	4,905,391			$	7,755,733			-$	56,083			-$	1,208,252			$	1,285,339
CAP		$	6,050,349			-$	1,220,740			$	10,614,223			$	949,776			$	75,336			$	3,308,975

(3) The following summarizes the valuation assumptions used for stock option awards included as part of CAP:

• Expected life of each stock option is based on the “simplified method” using an average of the remaining vest and remaining term, as of the vest/fiscal year end (FYE) date.

• Strike price is based on each grant date closing price and asset price is based on each vest/FYE closing price.

• Risk free rate is based on the Treasury Constant Maturity rate closest to the remaining expected life as of the vest/FYE date.

• Historical volatility is based on daily price history for each expected life (years) prior to each vest/FYE date. Closing prices provided by S&P Capital IQ are adjusted for dividends and splits.

• Represents annual dividend yield on each vest/FYE date.

(4) Non-PEO named executive officer averages reflect the following executives by year:

• 2024: Bruce Greenberg, Stephen G. Machatha, and Michael Alfieri

• 2022 and 2023: Bruce Greenberg, and Stephen G. Machatha

The dollar amounts reported in this column represent the average of the amounts reported for the non-PEO named executive officers in the “Total” column of the SCT in the applicable fiscal year.

(5) The dollar amounts reported represent the amount of net income (loss) reflected in our audited financial statements for the applicable year.

Named Executive Officers, Footnote

(4) Non-PEO named executive officer averages reflect the following executives by year:

• 2024: Bruce Greenberg, Stephen G. Machatha, and Michael Alfieri

• 2022 and 2023: Bruce Greenberg, and Stephen G. Machatha

The dollar amounts reported in this column represent the average of the amounts reported for the non-PEO named executive officers in the “Total” column of the SCT in the applicable fiscal year.

PEO Total Compensation Amount

$ 3,931,645

$ 3,684,651

$ 2,858,490

PEO Actually Paid Compensation Amount

$ 6,050,349

(1,220,740)

10,614,223

Adjustment To PEO Compensation, Footnote

(2) In accordance with SEC rules, deductions from and additions to, total compensation reported in the SCT by year to calculate Compensation Actually Paid include:

		Average Non-PEO named executive officers
		2024				2023				2022				2024				2023				2022
SCT Total		$	3,931,645			$	3,684,651			$	2,858,490			$	1,005,859			$	1,283,588			$	2,023,636
Adjustments for Equity Awards
Deduct:Grantdate values in SCT		-$	3,000,817			-$	2,850,548			-$	1,948,523			-$	608,498			-$	816,863			-$	1,535,579
Add:Year-endfair value of unvested awards granted in the current year		$	3,050,702			$	1,302,920			$	7,938,000			$	381,337			$	307,105			$	2,448,681
Add:Year-over-yeardifference of year-end fair values for unvested awards granted in prior years		$	1,137,053			-$	3,936,684			$	1,486,804			$	139,692			-$	969,744			$	179,149
Add:Fairvalues at vest date for awards granted and vested in current year		$	809,973			$	327,217			$	196,282			$	158,427			$	216,150			$	166,207
Add:Differencein fair values between prior year-end fair values and vest date fair values for awards granted in prior years		$	121,792			$	251,703			$	83,170			$	42,141			$	55,100			$	26,880
Deduct:Forfeituresduring current year equal to prior year-end fair value		$	0			$	0			$	0			-$	169,182			$	0			$	0
Total Adjustments for Equity Awards		$	2,118,704			-$	4,905,391			$	7,755,733			-$	56,083			-$	1,208,252			$	1,285,339
CAP		$	6,050,349			-$	1,220,740			$	10,614,223			$	949,776			$	75,336			$	3,308,975

Non-PEO NEO Average Total Compensation Amount

$ 1,005,859

1,283,588

2,023,636

Non-PEO NEO Average Compensation Actually Paid Amount

$ 949,776

75,336

3,308,975

Adjustment to Non-PEO NEO Compensation Footnote

(2) In accordance with SEC rules, deductions from and additions to, total compensation reported in the SCT by year to calculate Compensation Actually Paid include:

		Average Non-PEO named executive officers
		2024				2023				2022				2024				2023				2022
SCT Total		$	3,931,645			$	3,684,651			$	2,858,490			$	1,005,859			$	1,283,588			$	2,023,636
Adjustments for Equity Awards
Deduct:Grantdate values in SCT		-$	3,000,817			-$	2,850,548			-$	1,948,523			-$	608,498			-$	816,863			-$	1,535,579
Add:Year-endfair value of unvested awards granted in the current year		$	3,050,702			$	1,302,920			$	7,938,000			$	381,337			$	307,105			$	2,448,681
Add:Year-over-yeardifference of year-end fair values for unvested awards granted in prior years		$	1,137,053			-$	3,936,684			$	1,486,804			$	139,692			-$	969,744			$	179,149
Add:Fairvalues at vest date for awards granted and vested in current year		$	809,973			$	327,217			$	196,282			$	158,427			$	216,150			$	166,207
Add:Differencein fair values between prior year-end fair values and vest date fair values for awards granted in prior years		$	121,792			$	251,703			$	83,170			$	42,141			$	55,100			$	26,880
Deduct:Forfeituresduring current year equal to prior year-end fair value		$	0			$	0			$	0			-$	169,182			$	0			$	0
Total Adjustments for Equity Awards		$	2,118,704			-$	4,905,391			$	7,755,733			-$	56,083			-$	1,208,252			$	1,285,339
CAP		$	6,050,349			-$	1,220,740			$	10,614,223			$	949,776			$	75,336			$	3,308,975

Compensation Actually Paid vs. Total Shareholder Return

Relationship Between Compensation Actually Paid and Total Shareholder Return

The following chart illustrates the relationship between CAP to our PEO and Non-PEO NEOs (averaged), and the TSR over the reporting period. For our NEOs, a significant portion of’ compensation consists of equity awards. As a result, as demonstrated in the chart below, the amount of CAP to our NEOs is aligned with our cumulative TSR over the three-year period presented below.

Compensation Actually Paid vs. Net Income

Relationship Between Compensation Actually Paid and Net Income

The following chart illustrates the relationship between CAP to our PEO and Non-PEO NEO (averaged), and the Net Income over the reporting period. The CAP to our PEO and Non-PEO NEOs and Net Income is not correlated over the three years shown below. While we are required by SEC rules to disclose the relationship between our net income and compensation “actually paid” to our NEOs, this is not a metric our compensation committee currently uses in evaluating our NEOs compensation.

Total Shareholder Return Amount

$ 124.75

87.75

174

Net Income (Loss)

$ (55,851,000)

(37,543,000)

(62,025,000)

PEO Name

Todd C. Brady, M.D., Ph.D

PEO | Equity Awards Adjustments

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ 2,118,704

(4,905,391)

7,755,733

PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(3,000,817)

(2,850,548)

(1,948,523)

PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

3,050,702

1,302,920

7,938,000

PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

1,137,053

(3,936,684)

1,486,804

PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

809,973

327,217

196,282

PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

121,792

251,703

83,170

PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

0

0

0

Non-PEO NEO | Equity Awards Adjustments

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(56,083)

(1,208,252)

1,285,339

Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(608,498)

(816,863)

(1,535,579)

Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

381,337

307,105

2,448,681

Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

139,692

(969,744)

179,149

Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

158,427

216,150

166,207

Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

42,141

55,100

26,880

Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (169,182)

$ 0

$ 0

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- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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