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Convertible loan notes - Additional Information (Detail) - Novartis [member]
6 Months Ended
Jun. 30, 2022
£ / shares
Disclosure of detailed information about borrowings [line items]  
Conversion price per share £ 0.265
Borrowing interest rate 6.00%
Expiry date of warrants 2023-02
June 2020 private placement [member]  
Disclosure of detailed information about borrowings [line items]  
Conversion price per share £ 0.174
Borrowing interest rate 6.00%
Expiry date of warrants 2023-06