<SEC-DOCUMENT>0000899140-22-000343.txt : 20220214
<SEC-HEADER>0000899140-22-000343.hdr.sgml : 20220214
<ACCEPTANCE-DATETIME>20220214165045
ACCESSION NUMBER:		0000899140-22-000343
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220214
DATE AS OF CHANGE:		20220214
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Mereo Biopharma Group plc
		CENTRAL INDEX KEY:			0001719714
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91444
		FILM NUMBER:		22633824

	BUSINESS ADDRESS:	
		STREET 1:		ONE CAVENDISH PLACE
		STREET 2:		FOURTH FLOOR
		CITY:			LONDON
		STATE:			X0
		ZIP:			W1G0QF
		BUSINESS PHONE:		4403330237300

	MAIL ADDRESS:	
		STREET 1:		ONE CAVENDISH PLACE
		STREET 2:		FOURTH FLOOR
		CITY:			LONDON
		STATE:			X0
		ZIP:			W1G0QF

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>m020822a.htm
<DESCRIPTION>SCHEDULE 13G (AMENDMENT NO. 1)
<TEXT>
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    <div style="font-size: 12pt; font-weight: bold;">240.13d-102 Schedule 13G - Information to be included in statements filed</div>
    <div style="font-size: 12pt; font-weight: bold;">pursuant to 240.13d-1(b), (c), and (d) and amendments thereto</div>
    <div style="font-size: 12pt; font-weight: bold;">filed pursuant to 240.13d-2.</div>
    <div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">Securities and Exchange Commission, Washington, D.C. 20549</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Schedule 13G</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Under the Securities Exchange Act of 1934</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Amendment No. 1)*</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Name of Issuer)</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Mereo BioPharma Group plc</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Title of Class of Securities)</div>
    </div>
    <div>
      <div style="font-size: 12pt;">Ordinary shares, nominal value &#163;0.003 per ordinary share&#185;</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(CUSIP Number)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">589492107&#178;</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)</div>
    </div>
    <div style="font-size: 12pt;">December 31, 2021</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Check the appropriate box to designate the rule pursuant to which this</div>
    <div style="font-size: 12pt;">Schedule is filed:</div>
    <div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[&#160; ] Rule 13d-1(b)</div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[ x ] Rule 13d-1(c)</div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[&#160; ] Rule 13d-1(d)</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 5pt;"><font style="font-size: 12pt;">*The remainder of this cover page shall be filled out for a reporting person's<font style="font-size: 10pt;">&#160;</font>initial filing on this form with respect to the
          subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.<br>
          <br>
          The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but
          shall be subject to all other provisions of the Act (however, see the Notes).<br>
        </font>
        <div><br>
        </div>
        <div><br>
        </div>
        <div>
          <div><font style="font-family: 'Times New Roman',Times,serif;">1&#160; The holdings reported herein are held in the form of American Depositary Shares
              (&#8220;ADS&#8221;), which each represent five (5) ordinary shares, nominal value &#163;0.003 per ordinary share of the Issuer (&#8220;Ordinary Shares&#8221;).</font></div>
          <div><font style="font-size: 8pt;">2 &#160; </font> The CUSIP Number listed throughout this filing is the CUSIP
            assigned to the ADS of the Issuer.</div>
        </div>
        <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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      <div><br>
      </div>
    </div>
    <table cellspacing="0" cellpadding="3" border="0" id="z43d0d2b2d2d04ac99a7a486a1ea41774" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 589492107</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Asset Management, L.P.</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 9.1% (a) (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) PN</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 10pt; font-size: 12pt;"><br>
      *Consists of 10,610,000 American Depositary Shares, representing 53,050,000 Ordinary Shares.</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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    <table cellspacing="0" cellpadding="3" border="0" id="z3e12d154c4b64dcb8e29a7bc920b7ccb" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 589492107</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Capital Advisors, Inc.</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160;&#160; 10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 9.1% (a) (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) CO</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 10pt; font-size: 12pt;"><br>
      *Consists of 10,610,000 American Depositary Shares, representing 53,050,000 Ordinary Shares</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <table cellspacing="0" cellpadding="3" border="0" id="z62b828a71083481690c97a3dcba26610" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 589492107</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Steven A. Cohen</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization United States</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">10,610,000* (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 9.1% (a) (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) IN</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 10pt; font-size: 12pt;"><br>
      *Consists of 10,610,000 American Depositary Shares, representing 53,050,000 Ordinary Shares.</div>
    <div>
      <div><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after: always;" id="DSPFPageBreak">
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      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Item 1(a) Name of issuer:</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Mereo BioPharma Group plc</div>
    </div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Item 1(b) Address of issuer's principal executive offices:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">4th Floor, One Cavendish Place, London, W1G 0QF, United Kingdom</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(a) Name of person filing:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">The holdings of the Issuer&#8217;s ordinary shares, nominal value &#163;0.003 per share <br>
        (&#8220;Ordinary Shares&#8221;) reported herein are held in the form of American <br>
        Depositary Shares (&#8220;ADS&#8221;), which each represent five (5) Ordinary Shares.&#160; <br>
        This statement is filed by: (i) Point72 Asset Management, L.P. (&#8220;Point72 <br>
        Asset Management&#8221;) with respect to Ordinary Shares held, in the form of <br>
        ADSs, by certain investment funds it manages; (ii) Point72 Capital <br>
        Advisors, Inc. (&#8220;Point72 Capital Advisors Inc.&#8221;) with respect to Ordinary <br>
        Shares held, in the form of ADSs, by certain investment funds managed <br>
        by Point72 Asset Management; and (iii) Steven A. Cohen (&#8220;Mr. Cohen&#8221;) <br>
        with respect to Ordinary Shares held, in the form of ADSs, beneficially <br>
        owned by Point72 Asset Management and Point72 Capital Advisors Inc.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(b) Address or principal business office or, if none, residence:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">The address of the principal business office of Point72 Asset Management,<br>
        Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road,<br>
        Stamford, CT 06902.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(c) Citizenship:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Point72 Asset Management is a Delaware limited partnership. Point72 Capital <br>
        Advisors Inc. is a Delaware corporation. Mr. Cohen is a United States citizen.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(d) Title of class of securities:</div>
    </div>
    <div>
      <div style="font-size: 12pt;">Ordinary Shares, nominal value &#163;0.003 per ordinary share</div>
    </div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(e) CUSIP Number:</div>
    </div>
    <div>
      <div style="font-size: 12pt;">589492107</div>
    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt; font-style: italic;">Item 3.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 4. </font>Ownership</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">As of the close of business on December 31, 2021:</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">1. Point72 Asset Management, L.P.</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 10,610,000</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 9.1% (a)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt"> <br>
      </font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 10,610,000</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 10,610,000</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">2. Point72 Capital Advisors, Inc.</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 10,610,000</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 9.1% (a)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt"> <br>
      </font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 10,610,000</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 10,610,000</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">3. Steven A. Cohen</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 10,610,000</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 9.1% (a)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt"> <br>
      </font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 10,610,000</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 10,610,000</div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own<br>
        directly no ADSs or Ordinary Shares. Pursuant to an investment management <br>
        agreement, Point72 Asset Management maintains investment and voting power <br>
        with respect to the securities held by certain investment funds it manages. Point72 <br>
        Capital Advisors Inc. is the general partner of Point72 Asset Management. <br>
        Mr. Cohen controls each of Point72 Asset Management and Point72 Capital <br>
        Advisors Inc. As of December 31, 2021, by reason of the provisions of Rule <br>
        13d-3 of the Securities Exchange Act of 1934, as amended, each of Point72 <br>
        Asset Management, Point72 Capital Advisors Inc. and Mr. Cohen may be <br>
        deemed to beneficially own 10,610,000 Ordinary Shares (constituting <br>
        approximately 9.1% (a) of the Ordinary Shares outstanding). Each of Point72 <br>
        Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen disclaims <br>
        beneficial ownership of any of the securities covered by this statement.</div>
    </div>
    <font style="font-size: 12pt;">(a) This calculation is based on 116,495,802 ADSs outstanding as of December </font><font style="font-size: 12pt;"> <br>
      31, 2021, as disclosed on the Issuer&#8217;s Investor Share Data website.</font>
    <div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 5. </font>Ownership of 5 Percent or Less of a Class.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">If this statement is being filed to report the fact that as of the date hereof</div>
    <div style="font-size: 12pt;">the reporting person has ceased to be the beneficial owner of more than</div>
    <div style="font-size: 12pt;">5 percent of the class of securities, check the following [].</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 6.</font>&#160; Ownership of More than 5 Percent on Behalf of Another Person.</div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 7.</font>&#160; Identification and Classification of the Subsidiary Which Acquired</div>
    <div style="font-size: 12pt;">the Security Being Reporting on by the Parent Holding Company or Control</div>
    <div style="font-size: 12pt;">Person.</div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">Not applicable</div>
      <div style="margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;"><font style="font-style: italic;">Item 8. </font>Identification and Classification of Members of the Group</div>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 9.</font>&#160; Notice of Dissolution of Group.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 10. </font>Certifications</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By signing below I certify that, to the best of my knowledge and belief,</div>
    <div style="font-size: 12pt;">the securities referred to above were not acquired and are not held for the purpose</div>
    <div style="font-size: 12pt;">of or with the effect of changing or influencing the control of the issuer of</div>
    <div style="font-size: 12pt;">the securities and were not acquired and are not held in connection with or</div>
    <div style="font-size: 12pt;">as a participant in any transaction having that purpose or effect, other than <br>
      activities solely in connection with a nomination under&#167; 240.14a-11.</div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Signature.</font>&#160; After reasonable inquiry and to the best of my knowledge and belief,</div>
    <div style="font-size: 12pt;">I certify that the information set forth in this statement is true, complete</div>
    <div style="font-size: 12pt;">and correct.</div>
    <div>
      <div><br>
      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Dated: <u>February 14, 2022</u></div>
      <div><br>
      </div>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
    <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
    <div style="font-size: 12pt;">Title: Authorized Person</div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
    <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
    <div style="font-size: 12pt;">Title: Authorized Person</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">STEVEN A. COHEN</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
    <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
    <div style="font-size: 12pt;">Title: Authorized Person</div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
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