<SEC-DOCUMENT>0001415889-25-016764.txt : 20250611
<SEC-HEADER>0001415889-25-016764.hdr.sgml : 20250611
<ACCEPTANCE-DATETIME>20250611195148
ACCESSION NUMBER:		0001415889-25-016764
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250611
DATE AS OF CHANGE:		20250611

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Mereo BioPharma Group plc
		CENTRAL INDEX KEY:			0001719714
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91444
		FILM NUMBER:		251041291

	BUSINESS ADDRESS:	
		STREET 1:		ONE CAVENDISH PLACE
		STREET 2:		FOURTH FLOOR
		CITY:			LONDON
		STATE:			X0
		ZIP:			W1G0QF
		BUSINESS PHONE:		4403330237300

	MAIL ADDRESS:	
		STREET 1:		ONE CAVENDISH PLACE
		STREET 2:		FOURTH FLOOR
		CITY:			LONDON
		STATE:			X0
		ZIP:			W1G0QF

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Mereo Biopharma Group plc
		DATE OF NAME CHANGE:	20171016

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Northpond Ventures, LP
		CENTRAL INDEX KEY:			0001867472
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G

	BUSINESS ADDRESS:	
		STREET 1:		7500 OLD GEORGETOWN ROAD
		STREET 2:		SUITE 800
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
		BUSINESS PHONE:		240-800-1200

	MAIL ADDRESS:	
		STREET 1:		7500 OLD GEORGETOWN ROAD
		STREET 2:		SUITE 800
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <submissionType>SCHEDULE 13G</submissionType>
	    <filerInfo>
      <filer>
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          <cik>0001867472</cik>
          <ccc>XXXXXXXX</ccc>
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      </filer>
      <liveTestFlag>LIVE</liveTestFlag>





    </filerInfo>
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	      <securitiesClassTitle>Ordinary Shares, par value GBP 0.003 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/04/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001719714</issuerCik>        <issuerName>Mereo BioPharma Group plc</issuerName>        <issuerCusip>589492107</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>4th Floor, One Cavendish Place</com:street1>
                    <com:city>London</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>W1G 0QF</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>

	        <designateRulesPursuantThisScheduleFiled>
	   				        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
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    <reportingPersonName>Northpond Ventures, LP </reportingPersonName>

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		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>35223695.00</sharedVotingPower>
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                         <sharedDispositivePower>35223695.00</sharedDispositivePower>
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    <reportingPersonName>Northpond Ventures GP, LLC </reportingPersonName>

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    <reportingPersonName>Northpond Ventures II, LP</reportingPersonName>

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		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>16454455.00</sharedVotingPower>
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    <reportingPersonName>Northpond Ventures II GP, LLC</reportingPersonName>

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                <soleVotingPower>0.00</soleVotingPower>
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                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>16454455.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>OO</typeOfReportingPerson>



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    <reportingPersonName>NPV Listed, LLC</reportingPersonName>

	  		<memberGroup>b</memberGroup>


		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>2842850.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>2842850.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>OO</typeOfReportingPerson>



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    <reportingPersonName>Northpond Ventures, LLC</reportingPersonName>

	  		<memberGroup>b</memberGroup>


		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>2842850.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>2842850.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>OO</typeOfReportingPerson>



    </coverPageHeaderReportingPersonDetails>
	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Michael P. Rubin</reportingPersonName>

	  		<memberGroup>b</memberGroup>


		 <citizenshipOrOrganization>X1</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>54521000.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>54521000.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

              <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>54521000.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>


     	    <classPercent>6.9</classPercent>










	        <typeOfReportingPerson>IN</typeOfReportingPerson>




    </coverPageHeaderReportingPersonDetails>

    <items>
      <item1>
        <issuerName>Mereo BioPharma Group plc</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>4th Floor, One Cavendish Place, London, X0, W1G 0QF.</issuerPrincipalExecutiveOfficeAddress>
      </item1>

      <item2>
        <filingPersonName>The names of the persons filing this report (collectively, the "Reporting Persons") are:

Northpond Ventures, LP ("Northpond Fund")
Northpond Ventures GP, LLC ("Northpond GP LLC")
Northpond Ventures II, LP ("Northpond Fund II")
Northpond Ventures II GP, LLC ("Northpond GP II LLC")
NPV Listed, LLC ("NPV Listed")
Northpond Ventures, LLC ("Northpond Ventures")
Michael P. Rubin ("Rubin")

The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G.</filingPersonName>        <principalBusinessOfficeOrResidenceAddress>The principal business office of each Reporting Person is:

7500 Old Georgetown Road, Suite 800
Bethesda, MD 20814</principalBusinessOfficeOrResidenceAddress>        <citizenship>Northpond Fund		Delaware
Northpond GP LLC		Delaware
Northpond Fund II		Delaware
Northpond GP II LLC	Delaware
NPV Listed			Delaware
Northpond Ventures	Delaware
Rubin				United States
</citizenship>      </item2>

        <item3>
		        <notApplicableFlag>Y</notApplicableFlag>

      </item3>



    <item4>
    <amountBeneficiallyOwned>There is no CUSIP number assigned to the ordinary shares. CUSIP number 589492107 has been assigned to the American Depositary Shares ("ADSs") of the Issuer. Each ADS represents five ordinary shares.

Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of shares of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference.

The Reporting Persons' ownership of the Issuer's securities consists of (i) ordinary shares in the form of 7,044,739 ADSs directly held by Northpond Fund; (ii) ordinary shares in the form of 3,290,891 ADSs directly held by Northpond Fund II; (iii) ordinary shares in the form of 568,570 ADSs directly held by NPV Listed.

Northpond GP LLC is the general partner of Northpond Fund, Northpond GP II LLC is the general partner of Northpond Fund II and Northpond Ventures is the manager of NPV Listed.  Rubin is the managing member of each of Northpond GP LLC, Northpond GP II LLC and Northpond Ventures and has voting and dispositive power over the securities held by each of Northpond Fund, Northpond Fund II and NPV Listed.

</amountBeneficiallyOwned>    <classPercent>Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of the shares of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. The percentage set forth in each row 11 is based upon upon 795,001,444 ordinary shares outstanding as of May 12, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on May 13, 2025.</classPercent>
      <numberOfSharesPersonHas>
        <solePowerOrDirectToVote>Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference.</solePowerOrDirectToVote>
        <sharedPowerOrDirectToVote>Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference.</sharedPowerOrDirectToVote>
        <solePowerOrDirectToDispose>Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference.</solePowerOrDirectToDispose>
        <sharedPowerOrDirectToDispose>Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference.</sharedPowerOrDirectToDispose>
      </numberOfSharesPersonHas>
    </item4>


        <item5>
	          <notApplicableFlag>Y</notApplicableFlag>


    </item5>


        <item6>
	  	  <notApplicableFlag>Y</notApplicableFlag>
		        </item6>


        <item7>
	  	  <notApplicableFlag>Y</notApplicableFlag>


    </item7>


          <item8>
                <notApplicableFlag>Y</notApplicableFlag>

              </item8>


            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
                      </item9>


      <item10>
                <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>

      </item10>
    </items>

		<exhibitInfo>Exhibit 99.1	Joint Filing Agreement</exhibitInfo>

	    <signatureInformation>
      <reportingPersonName>Northpond Ventures, LP </reportingPersonName>

      <signatureDetails>
        <signature>/s/ Patrick Smerkers</signature>
        <title>By: Northpond Ventures GP, LLC, its General Partner, By Patrick Smerkers, Authorized Signatory</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Northpond Ventures GP, LLC </reportingPersonName>

      <signatureDetails>
        <signature>/s/ Patrick Smerkers</signature>
        <title>By Patrick Smerkers, Authorized Signatory</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Northpond Ventures II, LP</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Patrick Smerkers</signature>
        <title>By: Northpond Ventures II GP, LLC, its General Partner, By Patrick Smerkers, Authorized Signatory</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Northpond Ventures II GP, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Patrick Smerkers</signature>
        <title>By Patrick Smerkers, Authorized Signatory</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>NPV Listed, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Patrick Smerkers</signature>
        <title>By Northpond Ventures, LLC, its Manager, By Patrick Smerkers, CFO, Partner</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Northpond Ventures, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Patrick Smerkers</signature>
        <title>By Patrick Smerkers, CFO, Partner</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Michael P. Rubin</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Michael P. Rubin</signature>
        <title>Michael P. Rubin</title>
        <date>06/11/2025</date>
      </signatureDetails>

    </signatureInformation>



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</SEC-DOCUMENT>
