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Leases - Additional Information (Detail)
 1 Months Ended 12 Months Ended
Dec. 31, 2020
USD ($)
ft²
Oct. 31, 2020
USD ($)
ft²
May 31, 2019
ft²
Jun. 30, 2018
ft²
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Lessee Lease Description [Line Items]              
Tenant improvement allowance         $ 15,700,000    
Amount form letter of credit $ 1,472,000       $ 1,472,000 $ 1,472,000 $ 1,472,000
Lease expiration year         2029    
Operating lease, renewal period 10 years       10 years    
Operating lease term         The lease expires in 2029 with an option to renew for a period of ten years    
Operating sublease, impairment charges         $ 238,000 1,158,000  
Rent expense             $ 1,100,000
Weighted average remaining lease term for operating leases 8 years 2 months 12 days       8 years 2 months 12 days    
Weighted average discount rate for operating leases 8.50%       8.50%    
Cash paid for amounts included In measurement of lease liabilities         $ 6,900,000 $ 3,200,000  
Offices and Laboratory Facilities | South San Francisco              
Lessee Lease Description [Line Items]              
Area under lease | ft² 23,600     105,000      
Area under sublease | ft²     25,000        
Sublease expiration month and year         2021-11    
Operating sublease, option to extend         The sublessor has the option to extend the Sublease for one additional year subject to the consent of the Company.    
Sublease renewal period     1 year        
Operating sublease, existence of option to extend         true    
Ongoing loss over sublease period         $ 0    
Offices and Laboratory Facilities | South San Francisco | General and Administrative Expense              
Lessee Lease Description [Line Items]              
Operating sublease, impairment charges         $ 1,200,000    
Offices and Laboratory Facilities | South San Francisco              
Lessee Lease Description [Line Items]              
Tenant improvement allowance   $ 400,000          
Area of property | ft²   18,700          
Lease, description         In October 2020, the Company signed a lease agreement to lease approximately 18,700 square feet of office and laboratory space in Newark, California. The lease term ends on February 6, 2028 with an option to extend for an additional five years. The landlord is obligated to pay for up to $0.4 million of tenant improvements    
Lease expiration date   Feb. 06, 2028          
Extend for an additional lease term   5 years