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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Income Tax Disclosure [Abstract] |
Schedule of Federal and State Income Tax Provision | The federal and state income tax provision for the year ended December 31, 2022, 2021 and 2020 are summarized as follows (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
Current: |  |  |  |  |  |  |  |  |
Federal |  | $ | 2,209 |  |  | $ | — |  |  | $ | — |
State |  |  | 1,045 |  |  |  | — |  |  |  | — |
Income tax provision |  | $ | 3,254 |  |  | $ | — |  |  | $ | — |
Schedule of Effective Income Tax Rate Reconciliation | A reconciliation of the federal statutory rate to the Company’s effective tax rate is as follows for the years ended December 31, 2022, 2021, and 2020 (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
Tax benefit at federal statutory rate |  | $ | (27,205 | ) |  | $ | (7,627 | ) |  | $ | (39,948 | )
State income taxes |  |  | (344 | ) |  |  | 398 |  |  |  | (16,570 | )
Tax credits |  |  | (20,184 | ) |  |  | (9,389 | ) |  |  | (8,010 | )
Uncertain tax positions |  |  | 7,733 |  |  |  | 2,347 |  |  |  | 2,003 |
Stock-based compensation |  |  | 4,919 |  |  |  | (2,368 | ) |  |  | 353 |
Change in valuation allowance |  |  | 38,421 |  |  |  | 16,800 |  |  |  | 62,280 |
Other |  |  | (86 | ) |  |  | (161 | ) |  |  | (108 | )
Income tax provision |  | $ | 3,254 |  |  | $ | — |  |  | $ | — |
Schedule of Deferred Tax Assets and Liabilities | The tax effects of temporary differences that give rise to significant components of the Company’s deferred tax assets and liabilities consist of (in thousands):
|  | December 31, |
|  | 2022 |  |  | 2021 |
Deferred tax assets: |  |  |  |  |  |
Net operating loss |  | $ | 20,963 |  |  | $ | 63,868 |
Accrued bonus |  |  | 806 |  |  |  | 1,811 |
Tax credits |  |  | 26,319 |  |  |  | 19,614 |
Stock-based compensation |  |  | 13,351 |  |  |  | 9,656 |
Deferred revenue |  |  | 67,673 |  |  |  | 27,849 |
Lease liability |  |  | 10,055 |  |  |  | 11,296 |
Section 174 R&D capitalization |  |  | 35,150 |  |  |  | — |
Other |  |  | 1,608 |  |  |  | 694 |
Gross deferred tax assets |  |  | 175,925 |  |  |  | 134,788 |
Less valuation allowance |  |  | (164,316 | ) |  |  | (122,046 | )
Total deferred tax assets |  | $ | 11,609 |  |  | $ | 12,742 |
Deferred tax liabilities: |  |  |  |  |  |
Depreciation and amortization |  | $ | (5,155 | ) |  | $ | (5,488 | )
Right-of-use assets |  |  | (6,454 | ) |  |  | (7,254 | )
Gross deferred tax liabilities |  |  | (11,609 | ) |  |  | (12,742 | )
Deferred tax assets, net |  | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits | The following table summarizes the activity related to the Company’s unrecognized tax benefits for the years ended December 31, 2022, 2021, and 2020 (in thousands):
Balance as of December 31, 2020 |  | $ | 4,592 |
Decreases related to tax positions taken during the prior year |  |  | (59 | )
Increases related to tax positions taken during the current year |  |  | 2,406 |
Balance as of December 31, 2021 |  |  | 6,939 |
Increases related to tax positions taken during the current year |  |  | 8,199 |
Balance as of December 31, 2022 |  | $ | 15,138 |

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