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Leases - Additional Information (Detail)
$ in Thousands
 1 Months Ended 12 Months Ended
Jun. 30, 2018
ft²
Oct. 31, 2023
ft²
Feb. 28, 2023
ft²
Nov. 30, 2021
ft²
Dec. 31, 2020
ft²
Oct. 31, 2020
USD ($)
ft²
May 31, 2019
ft²
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2019
USD ($)
May 31, 2022
ft²
Lessee Lease Description [Line Items]                        
Tenant improvement allowance | $                     $ 15,700  
Amount form letter of credit | $               $ 1,546 $ 1,472      
Lease expiration year               2029        
Operating lease, renewal period               10 years        
Operating lease term               The lease expires in 2029 with an option to renew for a period of ten years.        
Weighted average remaining lease term for operating leases               5 years 2 months 12 days        
Weighted average discount rate for operating leases               8.50%        
Cash paid for amounts included In measurement of lease liabilities | $               $ 8,400 $ 8,200 $ 7,900    
Offices and Laboratory Facilities | South San Francisco                        
Lessee Lease Description [Line Items]                        
Area under lease | ft² 105,000       23,600              
Area under sublease | ft²     9,300 7,100     25,000          
Sublease expiration month and year   2024-11 2025-02           2022-12 2021-11    
Additional area sublease expiration month and year               2023-11        
Operating sublease, existence of option to extend                 true      
Additional area of property in lease | ft²   13,250                   13,150
Offices and Laboratory Facilities | South San Francisco                        
Lessee Lease Description [Line Items]                        
Tenant improvement allowance | $           $ 400            
Area of property | ft²           18,700            
Lease, description               In October 2020, the Company signed a lease agreement to lease approximately 18,700 square feet of office and laboratory space in Newark, California. The lease term ends on February 6, 2028 with an option to extend for an additional five years. The landlord is obligated to pay for up to $0.4 million of tenant improvements.        
Lease expiration date           Feb. 06, 2028            
Extend for an additional lease term           5 years