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Summary of Significant Accounting Policies - Summary of Segment Profit or Loss Including Significant Segment Expenses (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2026 | Mar. 31, 2026 | Jun. 30, 2025 | Mar. 31, 2025 | Jun. 30, 2026 | Jun. 30, 2025
Segment Reporting Information, Profit (Loss) [Abstract] |  |  |  |  |  |  |
Collaboration revenue |  | $ 3,320 |  | $ 7,874 |  | $ 4,366 | $ 11,548
Less: |  |  |  |  |  |  |
Compensation and benefits |  | 7,067 |  | 14,262 |  | 15,315 | 30,819
Lab expenses and outside research services |  | 4,809 |  | 2,903 |  | 8,256 | 6,127
Clinical supply costs |  | 3,028 |  | 3,873 |  | 4,407 | 6,947
Clinical trials |  | 1,371 |  | 7,081 |  | 4,755 | 14,094
Support functions |  | 6,123 |  | 7,701 |  | 12,423 | 15,987
Other segment expenses | [1] | 5,315 |  | 6,192 |  | 8,522 | 16,407
Total operating expenses |  | 27,713 |  | 42,012 |  | 53,678 | 90,381
Loss from operations |  | (24,393) |  | (34,138) |  | (49,312) | (78,833)
Other income, net |  | 1,533 |  | 3,614 |  | 3,522 | 7,838
Income tax |  | 130 |  | 0 |  | 130 | 0
Net loss |  | $ (22,990) | $ (22,930) | $ (30,524) | $ (40,471) | $ (45,920) | $ (70,995)
[1] | Other segment expenses include consultants & contractor expense, contra-R&D expense for GSK collaboration, depreciation expense, impairment loss, restructuring expense, and stock-based compensation expense.

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