<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>simulations_8kex99-1.txt
<DESCRIPTION>PRESS RELEASE, DATED NOVEMBER 4, 2005
<TEXT>
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                                                                    EXHIBIT 99.1


SIMULATIONS PLUS
Integrating Science and Software

For Further Information:
SIMULATIONS PLUS, INC.
1220 W. Avenue J
Lancaster, CA 93534-2902
661.723.7723
www.simulations-plus.com

CONTACT:
Investor Relations
------------------
Kevin McGrath
Cameron Associates
212.245.4577 (direct)
Kevin@cameronassoc.com

For Immediate Release:

November 4, 2005

             SIMULATIONS PLUS ACQUIRES ALL ASSETS OF BIOREASON, INC.

         ADDITIONAL PRODUCT AND SALES MOMENTUM COMPLEMENT PREVIOUS SAGE
                             INFORMATICS ACQUISITION

         LANCASTER, CA, NOVEMBER 4, 2005 -- Simulations Plus, Inc. (AMEX: SLP)
today announced that it has acquired all assets of Bioreason, Inc.
(www.bioreason.com) of Santa Fe, New Mexico, a chemistry software company
providing research tools to the pharmaceutical and biotechnology industries, in
an all-cash transaction for approximately $788,000.

         Walt Woltosz, chairman and chief executive officer of Simulations Plus
said, "Through this transaction, we have acquired all assets of Bioreason -
software, source code, two patents, trademarks, marketing and sales information,
as well as all fixed assets. This purchase completes the second phase of an
acquisition strategy we began in September with our purchase of the assets of
Sage Informatics, LLC including its ChemTK(TM) software. The capabilities of
Bioreason's flagship software, ClassPharmer(TM) and those of ChemTK complement
one another in pharmaceutical research, and we will integrate them into a single
product. The addition of Dr. David Miller, formerly of Sage Informatics, to our
Life Sciences Department provided us with an extremely high level of expertise
and software development talent for this area of chemical research. ClassPharmer
is currently licensed to over 30 companies in the U.S., Europe, and Japan.
Product loyalty among ClassPharmer users has been demonstrated by the very high
renewal rate for their annual licenses."

         Momoko Beran, chief financial officer of Simulations Plus added,
"Bioreason was founded in 1999. During the interim, the company invested over $9
million in the development of chemistry tools for pharmaceutical research.
ClassPharmer generated gross revenues of over $740,000 over the past 12 months.
The assets we have acquired include nearly $400,000 in accounts receivable from
multi-year licenses, with some of these due as early as this month. Most
companies license on an annual basis, and if all licenses that will expire
during this fiscal year are renewed, revenues from such licenses would be over
$500,000."

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         Ron Creeley, vice president of marketing and sales, commented, "This is
a truly exciting expansion of our pharmaceutical research software business. Our
due diligence contacts with current ClassPharmer customers resulted in 100%
enthusiastic feedback. Pharmaceutical scientists are finding its capabilities to
be invaluable in early discovery research. In addition, the purchase is
providing us access to new customer companies that are also strong prospective
buyers for our existing software lines."

         David Miller, Ph.D., senior scientist and former president of Sage
Informatics LLC, added, "One of the reasons I decided to sell Sage Informatics
and join Simulations Plus was the tremendous potential of merging ClassPharmer
with the ChemTK technologies developed at Sage. As a former Bioreason employee
involved in the initial design and development of ClassPharmer, I have extensive
experience with that product and its features, particularly its world-class
proprietary and patented algorithms for classifying chemical data. The one major
drawback of ClassPharmer has been its slow execution speed, which resulted from
the original choice of programming languages used to implement it. Because
ChemTK has a number of features in common with ClassPharmer, but has the
advantage of being at least ten times faster in typical analyses, there is great
potential for integrating these two products. By combining the speed and
flexibility of ChemTK with the advanced algorithms and features of ClassPharmer,
Simulations Plus will be able to offer chemists a much more powerful research
tool."


ABOUT SIMULATIONS PLUS, INC.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery
and development simulation software, which is licensed to and used in the
conduct of drug research by major pharmaceutical and biotechnology companies
worldwide. The Company has two other businesses, Words+, Inc. and FutureLab(TM),
which are based on its proprietary software technologies. Words+ has been in
business since 1981, and is known for developing the augmentative communication
device used by world-famous theoretical astrophysicist Sir Stephen Hawking,
Lucasian Professor of Mathematics at the University of Cambridge in England.
Simulations Plus, Inc., is headquartered in Southern California and trades on
the American Stock Exchange under the symbol "SLP." For more information, visit
our Web site at www.simulations-plus.com.


SAFE HARBOR STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995
- With the exception of historical information, the matters discussed in this
press release are forward-looking statements that involve a number of risks and
uncertainties. The actual future results of the Company could differ
significantly from those statements. Factors that could cause or contribute to
such differences include, but are not limited to: the ability of the Company to
market and support the ClassPharmer/ChemTK series of software products, the
general economics of the pharmaceutical industry, the ability of the Company to
attract and retain sufficient technical staff to sustain its R&D, sales, and
customer support functions, and a sustainable market. Further information on the
Company's risk factors is contained in the Company's quarterly and annual
reports as filed with the Securities and Exchange Commission.

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