-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 JxXkIF5axkoEvQJvS6jZ8NlFxuZ0V4OHhilYTePqpqiUepn+tViS+Wdr20aBbTEA
 MiiRKYpy1IiX6/7wB/Px3w==

<SEC-DOCUMENT>0001019687-05-003275.txt : 20051129
<SEC-HEADER>0001019687-05-003275.hdr.sgml : 20051129
<ACCEPTANCE-DATETIME>20051129080904
ACCESSION NUMBER:		0001019687-05-003275
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20051128
ITEM INFORMATION:		Completion of Acquisition or Disposition of Assets
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20051129
DATE AS OF CHANGE:		20051129

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SIMULATIONS PLUS INC
		CENTRAL INDEX KEY:			0001023459
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMPUTER INTEGRATED SYSTEMS DESIGN [7373]
		IRS NUMBER:				954595609
		FISCAL YEAR END:			0831

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32046
		FILM NUMBER:		051229797

	BUSINESS ADDRESS:	
		STREET 1:		1220 W. AVENUE J
		STREET 2:		*
		CITY:			LANCASTER
		STATE:			CA
		ZIP:			93534-2902
		BUSINESS PHONE:		661-723-7723

	MAIL ADDRESS:	
		STREET 1:		1220 W. AVENUE J
		CITY:			LANCASTER
		STATE:			CA
		ZIP:			93534-2902
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>simulations_8k-112805.txt
<TEXT>
<PAGE>

                                  UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934



                                November 28, 2005
                                -----------------
                      (Date of the earliest event reported)



                             Simulations Plus, Inc.
                             ----------------------
             (Exact name of Registrant as specified in its charter)


         California                   001-32046                 95-4595609
         ----------                   ---------                 ----------
(State or other jurisdiction   (Commission File Number)      (I.R.S. Employer
     of incorporation)                                      Identification No.)

                 1220 West Avenue J, Lancaster, California 93534
                 -----------------------------------------------
                    (Address of principal executive offices)
                                   (Zip Code)

                                 (661) 723-7723
                                 --------------
               Registrant's telephone number, including area code


                                       1
<PAGE>

ITEM 2.01. COMPLETION OF ACQUISITION OR DISPOSITION OF ASSETS

     On November 28, 2005, Simulations Plus, Inc., a California corporation (the
"Company") issued a press release announcing that it has terminated its former
investor relations agreement with Cameron and Associates and will move this
function in-house.

ITEM 8.01. OTHER EVENTS

(a) Exhibits

     99.1   Press release dated November 28, 2005



                                       2
<PAGE>

                                   Signatures

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                             SIMULATIONS PLUS, INC.



Dated: November 29, 2005                     By: /s/ Momoko Beran
                                                 ------------------------------
                                             Momoko A. Beran
                                             Chief Financial Officer



                                       3
<PAGE>

                                 EXHIBITS INDEX
                                 --------------


     Exhibit Number                                   Description
     --------------                                   -----------

          99.1                          Press release, dated November 28, 2005




                                       4
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>simulations_8k-ex9901.txt
<DESCRIPTION>PRESS RELEASE
<TEXT>
<PAGE>

                                                                    EXHIBIT 99.1


SIMULATIONS PLUS
Integrating Science and Software
For Further Information:
SIMULATIONS PLUS, INC.
1220 W. Avenue J
Lancaster, CA 93534-2902
661.723.7723
www.simulations-plus.com

CONTACT:
Investor Relations
Ms. Renee Bouche
Simulations Plus, Inc.
661.723.7723
info@simulations-plus.com

For Immediate Release:

November 28, 2005

             SIMULATIONS PLUS ANNOUNCES CHANGE IN INVESTOR RELATIONS

         FUNCTION TO BE MOVED IN-HOUSE FOR GREATER OPERATING EFFICIENCY

     LANCASTER, CA, NOVEMBER 28, 2005 --Simulations Plus, Inc. (AMEX: SLP), the
leading provider of ADMET absorption simulation and structure-to-property
prediction software for pharmaceutical discovery and development, announced
today that it has terminated its former investor relations agreement with
Cameron and Associates and will move this function in-house.

     Walt Woltosz, chairman and chief executive officer of Simulations Plus,
said, "As the company has grown and we have learned more about how to handle
investor relations issues, we have decided to do as many other companies have
done and bring this function in-house. We believe that this will provide greater
shareholder value through both a significant cost savings, as well as allowing a
greater number of person-hours to be applied to this function to provide a more
active IR program."

ABOUT SIMULATIONS PLUS, INC.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery
and development simulation software, which is licensed to and used in the
conduct of drug research by major pharmaceutical and biotechnology companies
worldwide. The Company has two other businesses, Words+, Inc. and FutureLab(TM),
which are based on its proprietary software technologies. Simulations Plus,
Inc., is headquartered in Southern California. For more information, visit our
Web site at www.simulations-plus.com.

###

                                       5
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
