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Consolidated Statements Of Stockholders' Equity (USD $) In Thousands, unless otherwise specified | Preferred Stock [Member] | Common Stock [Member] | Additional Paid-In Capital [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2008 | $ 9,496 | $ 33 | $ 410,444 | $ 212 | $ (385,907) | $ 34,278
Balance, shares at Dec. 31, 2008 | 3 | 32,544 |  |  |  |
Components of comprehensive loss: |  |  |  |  |  |
Net loss | 0 | 0 | 0 | 0 | (24,135) | (24,135)
Net change in unrealized gain (loss) on investments | 0 | 0 | 0 | (154) | 0 | (154)
Comprehensive loss |  |  |  |  |  | (24,289)
Issuance of common stock from public offering, net of expenses | 0 | 6 | 9,329 | 0 | 0 | 9,335
Issuance of common stock from public offering, net of expenses, shares |  | 6,000 |  |  |  |
Issuance of common stock from exercise of stock options and purchases from ESPP | 0 | 0 | 78 | 0 | 0 | 78
Issuance of common stock from exercise of stock options and purchases from ESPP, shares |  | 134 |  |  |  |
Stock-based compensation | 0 | 0 | 2,046 | 0 | 0 | 2,046
Balance at Dec. 31, 2009 | 9,496 | 39 | 421,897 | 58 | (410,042) | 21,448
Balance, shares at Dec. 31, 2009 | 3 | 38,678 |  |  |  |
Components of comprehensive loss: |  |  |  |  |  |
Net loss | 0 | 0 | 0 | 0 | (16,911) | (16,911)
Net change in unrealized gain (loss) on investments | 0 | 0 | 0 | 50 | 0 | 50
Comprehensive loss |  |  |  |  |  | (16,861)
Issuance of common stock from public offering, net of expenses | 0 | 8 | 16,940 | 0 | 0 | 16,948
Issuance of common stock from public offering, net of expenses, shares |  | 8,306 |  |  |  |
Issuance of common stock from exercise of stock options and purchases from ESPP | 0 | 0 | 369 | 0 | 0 | 369
Issuance of common stock from exercise of stock options and purchases from ESPP, shares |  | 345 |  |  |  |
Stock-based compensation | 0 | 0 | 1,828 | 0 | 0 | 1,828
Balance at Dec. 31, 2010 | 9,496 | 47 | 441,034 | 108 | (426,953) | 23,732
Balance, shares at Dec. 31, 2010 | 3 | 47,329 |  |  |  |
Components of comprehensive loss: |  |  |  |  |  |
Net loss | 0 | 0 | 0 | 0 | (16,982) | (16,982)
Net change in unrealized gain (loss) on investments | 0 | 0 | 0 | (108) | 0 | (108)
Comprehensive loss |  |  |  |  |  | (17,090)
Issuance of common stock from public offering, net of expenses | 0 | 4 | 9,674 | 0 | 0 | 9,678
Issuance of common stock from public offering, net of expenses, shares |  | 3,701 |  |  |  |
Issuance of common stock from exercise of stock options and purchases from ESPP | 0 | 0 | 143 | 0 | 0 | 143
Issuance of common stock from exercise of stock options and purchases from ESPP, shares |  | 181 |  |  |  |
Stock-based compensation | 0 | 0 | 1,850 | 0 | 0 | 1,850
Balance at Dec. 31, 2011 | $ 9,496 | $ 51 | $ 452,701 | $ 0 | $ (443,935) | $ 18,313
Balance, shares at Dec. 31, 2011 | 3 | 51,211 |  |  |  |

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- Definition The change in equity [net assets] of a business enterprise during a period from transactions and other events and circumstances from non-owner sources which are attributable to the economic entity, including both controlling (parent) and noncontrolling interests. It includes all changes in equity during a period except those resulting from investments by owners and distributions to owners, including any and all transactions which are directly or indirectly attributable to that ownership interest in subsidiary equity which is not attributable to the parent. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=6922042&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=6921628&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 51 -Paragraph A5 -Appendix A Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 51 -Paragraph 29 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 51 -Paragraph 38 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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