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Stockholders Equity - Additional Information (Detail) (USD $) | 12 Months Ended | 6 Months Ended | 12 Months Ended |  | 6 Months Ended | 1 Months Ended | 6 Months Ended | 12 Months Ended |  | 12 Months Ended
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Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2010 Maximum | Dec. 31, 2012 Stockholder Rights Plan | Jun. 30, 2012 Series B Convertible Preferred Stock | Dec. 31, 2012 Series B Convertible Preferred Stock | Mar. 31, 1999 Series B Convertible Preferred Stock | Jun. 30, 2012 Common Stock | Aug. 31, 2009 Warrant 2009 Unit Offering | Nov. 30, 2010 Warrant 2010 Unit Offering | Jun. 30, 2012 Warrant 2010 Unit Offering | Dec. 31, 2012 Sales Agreement Mlv | Dec. 31, 2011 Sales Agreement Mlv | Dec. 31, 2012 Sales Agreement Mlv Maximum | Dec. 31, 2012 Sales Agreement Cantor
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock issued | 0 | 3,000 |  |  |  |  |  | 3,327 |  |  |  |  |  |  |  |
Preferred stock conversion basis to common shares |  |  |  |  |  |  | 100 |  |  |  |  |  |  |  |  |
Redeemable preferred stock, amount |  |  |  |  |  | $ 9,500,000 |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock to Common stock |  |  |  |  |  | 3,327 |  |  |  |  |  |  |  |  |  |
Common stock issued to Fresenius |  |  |  |  |  |  |  |  | 332,700 |  |  |  |  |  |  |
Conversion of preferred stock to common stock date |  |  |  |  |  |  |  |  | Jun. 30, 2012 |  |  |  |  |  |  |
Warrants to purchase an aggregate shares of common stock |  |  |  |  |  |  |  |  |  | 2,400,000 | 3,700,000 |  |  |  |  |
warrant exercise price |  |  |  |  |  |  |  |  |  | 2.90 | 3.20 |  |  |  |  |
Exercisable period |  |  |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |  |
Warrant liability | 5,903,000 | 7,979,000 |  |  |  |  |  |  |  | 2,800,000 | 5,800,000 |  |  |  |  |
Risk-free rate |  |  |  |  |  |  |  |  |  | 2.48% | 1.23% |  |  |  |  |
Expected term |  |  |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |  |
Dividend yield |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% |  |  |  |  |
Volatility |  |  |  |  |  |  |  |  |  | 77.00% | 85.00% |  |  |  |  |
Net proceeds from underwritten public offering |  |  |  |  |  |  |  |  |  |  | 19,700,000 |  |  |  |  |
Payment for underwriting discounts and commissions and stock issuance cost | 550,000 | 420,000 | 1,710,000 |  |  |  |  |  |  |  | 1,300,000 |  |  |  |  |
Number of units sold in underwritten public offering |  |  |  |  |  |  |  |  |  |  | 7,400,000 |  |  |  |  |
Number of common stock in each unit |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |
Number of common stock shares purchasable with each warrant |  |  |  |  |  |  |  |  |  |  | 0.5 |  |  |  |  |
Units issues, price per unit |  |  |  |  |  |  |  |  |  |  | $ 2.85 |  |  |  |  |
Common stock, number of shares issued |  |  |  |  |  |  |  |  |  |  | 7,400,000 |  |  |  |  |
Warrants, number of common stock shares |  |  |  |  |  |  |  |  |  |  | 3,700,000 |  |  |  |  |
Warrants exercisable date |  |  |  |  |  |  |  |  |  |  | May 15, 2011 |  |  |  |  |
Revaluation of warrant liability | 2,059,000 | 486,000 | 39,000 | 100,000 |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised |  |  |  |  |  |  |  |  |  |  |  | 5,084 |  |  |  |
Maximum common stock offering price |  |  |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  | 30,000,000
Percentage of proceeds payable as compensation to underwriter |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  | 2.00%
Common stock, sold |  |  |  |  |  |  |  |  |  |  |  |  | 3,100,000 | 3,500,000 |  | 1,400,000
Proceeds from common stock sold | $ 14,226,000 | $ 9,273,000 | $ 19,291,000 |  |  |  |  |  |  |  |  |  | $ 9,500,000 | $ 9,700,000 |  | $ 4,300,000
Common stock available to be sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 25,500,000
Minimum percentage of common stock acquired by stockholders |  |  |  |  | 15.00% |  |  |  |  |  |  |  |  |  |  |
Designated preferred stock for future issuance |  |  |  |  | 250,000 |  |  |  |  |  |  |  |  |  |  |

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