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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Product related: |  |  |
Product revenue | $ 36,695 | $ 30,602 | $ 21,677
Cost of product revenue | 20,616 | 18,535 | 12,046
Gross profit on product revenue | 16,079 | 12,067 | 9,631
Government grants and cooperative agreements revenue | 91 | 2,442 | 1,432
Operating expenses: |  |  |
Research and development | 7,603 | 7,178 | 5,195
Selling, general and administrative | 25,665 | 23,053 | 21,577
Amortization of intangible assets | 202 | 202 | 67
Acquisition related costs net of gain on non-controlling equity interest | 0 | 0 | 182
Total operating expenses | 33,470 | 30,433 | 27,021
Loss from operations | (17,300) | (15,924) | (15,958)
Non-operating income (expense), net: |  |  |
Revaluation of warrant liability | 2,059 | 486 | 39
Foreign exchange gain (loss) | 86 | (529) | (816)
Interest expense | (551) | (964) | (689)
Other income, net | 31 | 92 | 607
Total non-operating income (expense), net | 1,625 | (915) | (859)
Loss before income taxes | (15,675) | (16,839) | (16,817)
Provision for income taxes | 242 | 143 | 94
Net loss | $ (15,917) | $ (16,982) | $ (16,911)
Net loss per common share: |  |  |
Basic | $ (0.29) | $ (0.35) | $ (0.42)
Diluted | $ (0.33) | $ (0.35) | $ (0.42)
Weighted average common shares outstanding used for calculating net loss per common share: |  |  |
Basic | 54,515 | 48,050 | 40,300
Diluted | 55,061 | 48,050 | 40,300

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- Definition Aggregate revenue during the period from the sale of goods in the normal course of business, after deducting returns, allowances and discounts. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1(a)) -URI http://asc.fasb.org/extlink&oid=6880815&loc=d3e20235-122688 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 1 -Article 5 + Details
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- Definition The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 43 -Paragraph 5A -Chapter 4 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 4 -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.4) -URI http://asc.fasb.org/extlink&oid=6880815&loc=d3e20235-122688 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 330 -SubTopic 10 -Section 30 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6386349&loc=d3e3636-108311 + Details
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