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Stockholders Equity - Additional Information (Detail) (USD $) | 3 Months Ended | 6 Months Ended |  | 6 Months Ended |  | 6 Months Ended | 12 Months Ended |  | 3 Months Ended | 12 Months Ended |  | 6 Months Ended |  | 6 Months Ended | 1 Months Ended | 6 Months Ended
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Jun. 30, 2013 | Jun. 30, 2012 | Jun. 30, 2013 | Jun. 30, 2012 | Dec. 31, 2012 | Jun. 30, 2013 IPO | Mar. 19, 2013 IPO | Jun. 30, 2013 IPO Overallotment Option | Jun. 30, 2013 Stockholder Rights Plan | Jun. 30, 2013 Sales Agreement Mlv | Dec. 31, 2012 Sales Agreement Mlv | Jun. 30, 2013 Sales Agreement Mlv Maximum | Mar. 31, 2013 Sales Agreement Cantor | Dec. 31, 2012 Sales Agreement Cantor | Jun. 30, 2013 Sales Agreement Cantor | Jun. 30, 2013 Series B Preferred Stock | Jun. 30, 2012 Series B Preferred Stock | Mar. 31, 1999 Series B Preferred Stock | Jun. 30, 2012 Common Stock | Aug. 31, 2009 Warrant 2009 Unit Offering | Nov. 30, 2010 Warrant 2010 Unit Offering | Jun. 30, 2013 Warrant 2010 Unit Offering
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,327 |  |  |  |
Preferred stock conversion basis to common shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100 |  |  |  |  |  |
Redeemable preferred stock, amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 9,500,000 |  |  |  |  |
Conversion of preferred stock to Common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,327 |  |  |  |  |
Common stock issued to Fresenius |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 332,700 |  |  |
Conversion of preferred stock to common stock date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Jun. 30, 2012 |  |  |
Warrants to purchase an aggregate shares of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,400,000 | 3,700,000 |
Net proceeds from underwritten public offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,100,000 | 19,700,000 |
Payment for underwriting discounts and commissions and stock issuance cost |  |  |  |  |  | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,100,000 | 1,300,000 |
Number of units sold in underwritten public offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,000,000 | 7,400,000 |
Number of common stock in each unit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 | 1 |
Number of common stock shares purchasable with each warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.4 | 0.5 |
Units issues, price per unit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.20 |  |
Common stock, number of shares issued |  |  |  |  |  |  |  |  |  | 6,600,000 |  |  | 3,800,000 | 1,400,000 |  |  |  |  |  | 6,000,000 | 7,400,000 |
Warrant exercise price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.90 | 3.20 |
Exercisable period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years |
Warrant liability | 10,290,000 |  | 10,290,000 |  | 5,903,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,800,000 | 5,800,000 |
Risk-free rate |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.48% | 1.23% |
Expected term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years |
Dividend yield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% |
Volatility |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 77.00% | 85.00% |
Units issued, price per unit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.85 |
Warrants, number of common stock shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,700,000 |
Warrants exercisable date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | May 15, 2011 |
Gain (Loss) from Revaluation of warrant liability | 686,000 | 3,674,000 | (4,387,000) | (787,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,084
Maximum common stock offering price |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  | 30,000,000 |  |  |  |  |  |  |  |
Percentage of proceeds payable as compensation to underwriter |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  | 2.00% |  |  |  |  |  |  |  |
Proceeds from common stock sold |  |  | 51,171,000 | 9,876,000 |  | 38,000,000 |  |  |  | 19,200,000 |  |  | 13,000,000 | 4,300,000 |  |  |  |  |  |  |  |
Common stock available for sale |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  | 12,500,000 |  |  |  |  |  |  |
Common stock, number of shares issued |  |  |  |  |  | 8,300,000 |  | 1,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, price per share |  |  |  |  |  |  | $ 4.20 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds from public offering |  |  |  |  |  | 40,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Underwriter's discount |  |  |  |  |  | $ 1,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Minimum percentage of common stock acquired by stockholders |  |  |  |  |  |  |  |  | 15.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Designated preferred stock for future issuance |  |  |  |  |  |  |  |  | 250,000 |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition Value of outstanding derivative securities that permit the holder the right to purchase securities (usually equity) from the issuer at a specified price. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph i -Article 4 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant