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Stockholders Equity - Additional Information (Detail) (USD $)
 3 Months Ended 6 Months Ended 6 Months Ended 6 Months Ended 12 Months Ended 3 Months Ended 12 Months Ended 6 Months Ended 6 Months Ended 1 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Dec. 31, 2012
Jun. 30, 2013
IPO
Mar. 19, 2013
IPO
Jun. 30, 2013
IPO
Overallotment Option
Jun. 30, 2013
Stockholder Rights Plan
Jun. 30, 2013
Sales Agreement
Mlv
Dec. 31, 2012
Sales Agreement
Mlv
Jun. 30, 2013
Sales Agreement
Mlv
Maximum
Mar. 31, 2013
Sales Agreement
Cantor
Dec. 31, 2012
Sales Agreement
Cantor
Jun. 30, 2013
Sales Agreement
Cantor
Jun. 30, 2013
Series B Preferred Stock
Jun. 30, 2012
Series B Preferred Stock
Mar. 31, 1999
Series B Preferred Stock
Jun. 30, 2012
Common Stock
Aug. 31, 2009
Warrant
2009 Unit Offering
Nov. 30, 2010
Warrant
2010 Unit Offering
Jun. 30, 2013
Warrant
2010 Unit Offering
Stockholders Equity Note [Line Items]                                            
Preferred stock issued                                   3,327        
Preferred stock conversion basis to common shares                               100            
Redeemable preferred stock, amount                                 $ 9,500,000          
Conversion of preferred stock to Common stock                                 3,327          
Common stock issued to Fresenius                                     332,700      
Conversion of preferred stock to common stock date                                     Jun. 30, 2012      
Warrants to purchase an aggregate shares of common stock                                       2,400,000 3,700,000  
Net proceeds from underwritten public offering                                       12,100,000 19,700,000  
Payment for underwriting discounts and commissions and stock issuance cost           500,000                           1,100,000 1,300,000  
Number of units sold in underwritten public offering                                       6,000,000 7,400,000  
Number of common stock in each unit                                       1 1  
Number of common stock shares purchasable with each warrant                                       0.4 0.5  
Units issues, price per unit                                       $ 2.20    
Common stock, number of shares issued                   6,600,000     3,800,000 1,400,000           6,000,000 7,400,000  
Warrant exercise price                                       2.90 3.20  
Exercisable period                                       5 years 5 years  
Warrant liability 10,290,000   10,290,000   5,903,000                             2,800,000 5,800,000  
Risk-free rate                                       2.48% 1.23%  
Expected term                                       5 years 5 years  
Dividend yield                                       0.00% 0.00%  
Volatility                                       77.00% 85.00%  
Units issued, price per unit                                         $ 2.85  
Warrants, number of common stock shares                                         3,700,000  
Warrants exercisable date                                         May 15, 2011  
Gain (Loss) from Revaluation of warrant liability 686,000 3,674,000 (4,387,000) (787,000)                                    
Warrants exercised                                           5,084
Maximum common stock offering price                     20,000,000     30,000,000                
Percentage of proceeds payable as compensation to underwriter                     3.00%     2.00%                
Proceeds from common stock sold     51,171,000 9,876,000   38,000,000       19,200,000     13,000,000 4,300,000                
Common stock available for sale                       100,000     12,500,000              
Common stock, number of shares issued           8,300,000   1,300,000                            
Common stock, price per share             $ 4.20                              
Gross proceeds from public offering           40,300,000                                
Underwriter's discount           $ 1,800,000                                
Minimum percentage of common stock acquired by stockholders                 15.00%                          
Designated preferred stock for future issuance                 250,000