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Summary of Quarterly Financial Information (Detail) (USD $) In Thousands, except Per Share data, unless otherwise specified | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2013 | Sep. 30, 2013 | Jun. 30, 2013 | Mar. 31, 2013 | Dec. 31, 2012 | Sep. 30, 2012 | Jun. 30, 2012 | Mar. 31, 2012 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Quarterly Financial Information [Line Items] |  |  |  |  |  |  |  |  |  |  |
Product revenue | $ 9,232 | $ 10,542 | $ 10,150 | $ 9,733 | $ 10,528 | $ 8,252 | $ 9,224 | $ 8,691 | $ 39,657 | $ 36,695 | $ 30,602
Cost of product revenue | 4,939 | 6,826 | 5,747 | 5,090 | 5,117 | 4,411 | 5,574 | 5,514 | 22,602 | 20,616 | 18,535
Gross profit on product revenue | 4,293 | 3,716 | 4,403 | 4,643 | 5,411 | 3,841 | 3,650 | 3,177 | 17,055 | 16,079 | 12,067
Government grants and cooperative agreements revenue |  |  |  |  |  |  |  | 91 | 0 | 91 | 2,442
Research and development | 4,618 | 4,363 | 3,506 | 2,700 | 2,164 | 1,903 | 1,712 | 1,824 | 15,187 | 7,603 | 7,178
Selling, general and administrative | 7,430 | 7,728 | 7,954 | 6,853 | 6,794 | 6,219 | 6,686 | 5,966 | 29,965 | 25,665 | 23,053
Amortization of intangible assets | 51 | 50 | 51 | 50 | 51 | 50 | 51 | 50 | 202 | 202 | 202
Total operating expenses | 12,099 | 12,141 | 11,511 | 9,603 | 9,009 | 8,172 | 8,449 | 7,840 | 45,354 | 33,470 | 30,433
Loss from operations | (7,806) | (8,425) | (7,108) | (4,960) | (3,598) | (4,331) | (4,799) | (4,572) | (28,299) | (17,300) | (15,924)
Total non-operating income (expense), net | 1,999 | (12,016) | 438 | (5,241) | 1,993 | 926 | 2,933 | (4,227) | (14,820) | 1,625 | (915)
Loss before income taxes | (5,807) | (20,441) | (6,670) | (10,201) | (1,605) | (3,405) | (1,866) | (8,799) | (43,119) | (15,675) | (16,839)
Provision for income taxes | 53 | 60 | 54 | 51 | 111 | 55 | 41 | 35 | 218 | 242 | 143
Net loss | $ (5,860) | $ (20,501) | $ (6,724) | $ (10,252) | $ (1,716) | $ (3,460) | $ (1,907) | $ (8,834) | $ (43,337) | $ (15,917) | $ (16,982)
Basic | $ (0.08) | $ (0.29) | $ (0.10) | $ (0.17) | $ (0.03) | $ (0.06) | $ (0.04) | $ (0.17) | $ (0.64) | $ (0.29) | $ (0.35)
Diluted | $ (0.10) | $ (0.29) | $ (0.10) | $ (0.17) | $ (0.07) | $ (0.08) | $ (0.10) | $ (0.17) | $ (0.64) | $ (0.33) | $ (0.35)

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