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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $) In Thousands | Total | Preferred Stock | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2010 | $ 23,732 | $ 9,496 | $ 47 | $ 441,034 | $ 108 | $ (426,953)
Beginning Balance (in shares) at Dec. 31, 2010 |  | 3 | 47,329 |  |  |
Net loss | (16,982) |  |  |  |  | (16,982)
Other comprehensive income | (108) |  |  |  | (108) |
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 (in shares) |  |  | 3,701 |  |  |
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 | 9,678 |  | 4 | 9,674 |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares) |  |  | 181 |  |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP | 143 |  |  | 143 |  |
Stock-based compensation | 1,850 |  |  | 1,850 |  |
Ending Balance at Dec. 31, 2011 | 18,313 | 9,496 | 51 | 452,701 |  | (443,935)
Ending Balance (in shares) at Dec. 31, 2011 |  | 3 | 51,211 |  |  |
Net loss | (15,917) |  |  |  |  | (15,917)
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 (in shares) |  |  | 4,487 |  |  |
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 | 13,821 |  | 5 | 13,816 |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares) |  |  | 221 |  |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP | 349 |  |  | 349 |  |
Preferred stock conversion (in shares) |  | (3) | 333 |  |  |
Preferred stock conversion |  | (9,496) |  | 9,496 |  |
Stock-based compensation | 2,541 |  |  | 2,541 |  |
Ending Balance at Dec. 31, 2012 | 19,107 |  | 56 | 478,903 |  | (459,852)
Ending Balance (in shares) at Dec. 31, 2012 |  |  | 56,252 |  |  |
Net loss | (43,337) |  |  |  |  | (43,337)
Other comprehensive income | 7 |  |  |  | 7 |
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 (in shares) |  |  | 15,019 |  |  |
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 | 61,454 |  | 15 | 61,439 |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares) |  |  | 588 |  |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP | 2,296 |  | 1 | 2,295 |  |
Stock-based compensation | 3,268 |  |  | 3,268 |  |
Ending Balance at Dec. 31, 2013 | $ 42,795 |  | $ 72 | $ 545,905 | $ 7 | $ (503,189)
Ending Balance (in shares) at Dec. 31, 2013 |  |  | 71,859 |  |  |

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