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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $)
In Thousands
Total
Preferred Stock
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income
Accumulated Deficit
Beginning Balance at Dec. 31, 2010 $ 23,732 $ 9,496 $ 47 $ 441,034 $ 108 $ (426,953)
Beginning Balance (in shares) at Dec. 31, 2010   3 47,329      
Net loss (16,982)         (16,982)
Other comprehensive income (108)       (108)  
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 (in shares)     3,701      
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 9,678   4 9,674    
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares)     181      
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP 143     143    
Stock-based compensation 1,850     1,850    
Ending Balance at Dec. 31, 2011 18,313 9,496 51 452,701   (443,935)
Ending Balance (in shares) at Dec. 31, 2011   3 51,211      
Net loss (15,917)         (15,917)
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 (in shares)     4,487      
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 13,821   5 13,816    
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares)     221      
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP 349     349    
Preferred stock conversion (in shares)   (3) 333      
Preferred stock conversion   (9,496)   9,496    
Stock-based compensation 2,541     2,541    
Ending Balance at Dec. 31, 2012 19,107   56 478,903   (459,852)
Ending Balance (in shares) at Dec. 31, 2012     56,252      
Net loss (43,337)         (43,337)
Other comprehensive income 7       7  
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 (in shares)     15,019      
Issuance of common stock from public offering, net of expenses of $2,733 for 2013, $550 for 2012 , and $420 for 2011 61,454   15 61,439    
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares)     588      
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP 2,296   1 2,295    
Stock-based compensation 3,268     3,268    
Ending Balance at Dec. 31, 2013 $ 42,795   $ 72 $ 545,905 $ 7 $ (503,189)
Ending Balance (in shares) at Dec. 31, 2013     71,859