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Stockholders Equity - Additional Information (Detail) (USD $)
 12 Months Ended 12 Months Ended 6 Months Ended 12 Months Ended 6 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2013
2009 Unit Offering
Dec. 31, 2013
2010 Unit Offering
Dec. 31, 2013
Stockholder Rights Plan
Jun. 30, 2012
Series B Preferred Stock
Dec. 31, 2013
Series B Preferred Stock
Mar. 31, 1999
Series B Preferred Stock
Jun. 30, 2012
Common Stock
Aug. 31, 2009
Warrant
2009 Unit Offering
Nov. 30, 2010
Warrant
2010 Unit Offering
Dec. 31, 2013
Warrant
2010 Unit Offering
Dec. 31, 2012
Warrant
2010 Unit Offering
Dec. 31, 2013
Sales Agreement
Mlv
Dec. 31, 2012
Sales Agreement
Mlv
Dec. 31, 2011
Sales Agreement
Mlv
Dec. 31, 2013
Sales Agreement
Mlv
Maximum
Dec. 31, 2013
Sales Agreement
Cantor
Dec. 31, 2012
Sales Agreement
Cantor
Stockholders Equity Note [Line Items]                                        
Preferred stock issued 0 0             3,327                      
Preferred stock conversion basis to common shares               100                        
Redeemable preferred stock, amount             $ 9,500,000                          
Conversion of preferred stock to Common stock             3,327                          
Common stock issued to Fresenius                   332,700                    
Conversion of preferred stock to common stock date                   Jun. 30, 2012                    
Warrants to purchase an aggregate shares of common stock                     2,400,000 3,700,000                
Warrant exercise price                     2.90 3.20                
Exercisable period                     5 years 5 years                
Warrant liability 20,390,000 5,903,000   5,900,000 5,900,000           2,800,000 5,800,000                
Risk-free rate                     2.48% 1.23%                
Expected term                     5 years 5 years                
Dividend yield                     0.00% 0.00%                
Volatility                     77.00% 85.00%                
Net proceeds from underwritten public offering                       19,700,000                
Payment for underwriting discounts and commissions and stock issuance cost 2,733,000 550,000 420,000                 1,300,000                
Number of units sold in underwritten public offering                       7,400,000                
Number of common stock in each unit                       1                
Number of common stock shares purchasable with each warrant                       0.5                
Units issued, price per unit                       $ 2.85                
Common stock, number of shares issued                       7,400,000       3,100,000 3,500,000   5,400,000 1,400,000
Warrants exercisable date                       May 15, 2011                
Gain (Loss) from Revaluation of warrant liability (15,099,000) 2,059,000 486,000                                  
Warrants exercised       0                 200,000 5,000.0            
Maximum common stock offering price                             20,000,000       30,000,000  
Percentage of proceeds payable as compensation to underwriter                             3.00%       2.00%  
Proceeds from common stock sold 61,425,000 14,226,000 9,273,000                         9,500,000 9,700,000   23,500,000 4,300,000
Common stock available for sale                                   $ 100,000 $ 1,500,000  
Minimum percentage of common stock acquired by stockholders           15.00%                            
Designated preferred stock for future issuance           250,000