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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2015 | Sep. 30, 2014
Operating activities |  |  |
Net loss | $ (41,112) |  | $ (18,573)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,229 |  | 989
Stock-based compensation | 4,912 |  | 3,764
Gain from revaluation of warrant liability | (4,698) |  | (14,263)
Non-cash interest expense | 230 |  | 65
Deferred income taxes | 12 |  | 19
Loss on disposal of fixed assets |  |  | 3
Tax benefit from other unrealized gain on available-for-sale securities | (2,034) |  |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (153) |  | (1,241)
Inventories | 1,970 |  | (632)
Other assets | 802 |  | (2,860)
Accounts payable | (3,085) |  | (1,555)
Accrued liabilities | (375) |  | 2,728
Deferred revenue | (42) |  | 379
Net cash used in operating activities | (42,344) |  | (31,177)
Investing activities |  |  |
Capital expenditures | (561) |  | (2,033)
Purchases of investments | (78,261) |  | (14,807)
Proceeds from maturities of investments | 57,444 |  | 17,305
Proceeds from sales of certain other assets |  |  | 50
Restricted cash | (115) |  |
Net cash (used in) provided by investing activities | (21,493) |  | 515
Financing activities |  |  |
Net proceeds from equity incentive plans and warrants | 6,609 |  | 10,269
Net proceeds from public offering | 75,327 |  | 6,849
Proceeds from loans, net of discount | 10,000 |  | 9,848
Repayment of debt | (85) |  | (3,446)
Net cash provided by financing activities | 91,851 |  | 23,520
Net increase (decrease) in cash and cash equivalents | 28,014 |  | (7,142)
Cash and cash equivalents, beginning of period | 22,781 | [1] | 29,485
Cash and cash equivalents, end of period | $ 50,795 |  | $ 22,343
[1] | The financial information in this column was derived from audited consolidated financial statements included in the Company's 2014 Annual Report on Form 10-K.

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- Definition Amount of cash inflow from contractual arrangement with the lender, including but not limited to, letter of credit, standby letter of credit and revolving credit arrangements. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(f)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=49167202&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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