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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Operating activities    
Net loss $ (41,112) $ (18,573)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,229 989
Stock-based compensation 4,912 3,764
Gain from revaluation of warrant liability (4,698) (14,263)
Non-cash interest expense 230 65
Deferred income taxes 12 19
Loss on disposal of fixed assets   3
Tax benefit from other unrealized gain on available-for-sale securities (2,034)  
Changes in operating assets and liabilities:    
Accounts receivable (153) (1,241)
Inventories 1,970 (632)
Other assets 802 (2,860)
Accounts payable (3,085) (1,555)
Accrued liabilities (375) 2,728
Deferred revenue (42) 379
Net cash used in operating activities (42,344) (31,177)
Investing activities    
Capital expenditures (561) (2,033)
Purchases of investments (78,261) (14,807)
Proceeds from maturities of investments 57,444 17,305
Proceeds from sales of certain other assets   50
Restricted cash (115)  
Net cash (used in) provided by investing activities (21,493) 515
Financing activities    
Net proceeds from equity incentive plans and warrants 6,609 10,269
Net proceeds from public offering 75,327 6,849
Proceeds from loans, net of discount 10,000 9,848
Repayment of debt (85) (3,446)
Net cash provided by financing activities 91,851 23,520
Net increase (decrease) in cash and cash equivalents 28,014 (7,142)
Cash and cash equivalents, beginning of period 22,781 [1] 29,485
Cash and cash equivalents, end of period $ 50,795 $ 22,343
[1] The financial information in this column was derived from audited consolidated financial statements included in the Company's 2014 Annual Report on Form 10-K.