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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2015
United States and Foreign Components of Consolidated Loss Before Income Taxes | U.S and foreign components of consolidated loss before income taxes for the years ended December 2015, 2014 and 2013, was as follows (in thousands):
|  | Year Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Loss before income taxes: |  |  |  |  |  |  |  |  |  |  |  |
U.S. |  | $ | (59,897 | ) |  | $ | (38,928 | ) |  | $ | (44,035 | )
Foreign |  |  | 358 |  |  |  | 368 |  |  |  | 916 |
Loss before income taxes |  | $ | (59,539 | ) |  | $ | (38,560 | ) |  | $ | (43,119 | )
Provision Benefit for Income Taxes | The provision for income taxes for the years ended December 2015, 2014 and 2013, was as follows (in thousands):
|  | Year Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Provision for income taxes: |  |  |  |  |  |  |  |  |  |  |  |
Current: |  |  |  |  |  |  |  |  |  |  |  |
Foreign |  | $ | 147 |  |  | $ | 168 |  |  | $ | 191 |
Federal |  |  | — |  |  |  | — |  |  |  | — |
State |  |  | — |  |  |  | 1 |  |  |  | — |
Total Current |  |  | 147 |  |  |  | 169 |  |  |  | 191 |
Deferred: |  |  |  |  |  |  |  |  |  |  |  |
Foreign |  |  | — |  |  |  | — |  |  |  | — |
Federal |  |  | (3,750 | ) |  |  | 22 |  |  |  | 21 |
State |  |  | (68 | ) |  |  | 4 |  |  |  | 6 |
Total Deferred |  |  | (3,818 | ) |  |  | 26 |  |  |  | 27 |
(Benefit) provision for income taxes |  | $ | (3,671 | ) |  | $ | 195 |  |  | $ | 218 |
Difference Between Provision for Income Taxes and Amounts Computed by Applying Federal Statutory Income Tax Rate to Loss before Taxes | The difference between the provision for income taxes and the amount computed by applying the federal statutory income tax rate to loss before taxes for the years ended December 31, 2015, 2014 and 2013, was as follows (in thousands):
|  | Year Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Federal statutory tax |  | $ | (20,243 | ) |  | $ | (13,110 | ) |  | $ | (14,661 | )
Warrants |  |  | (3,565 | ) |  |  | (3,367 | ) |  |  | 4,926 |
Expiration of federal loss carryovers |  |  | 3,337 |  |  |  | — |  |  |  | — |
Change in valuation allowance |  |  | 11,754 |  |  |  | 16,576 |  |  |  | 9,955 |
Change in state apportionment |  |  | 4,085 |  |  |  | — |  |  |  | — |
Other |  |  | 961 |  |  |  | 96 |  |  |  | (2 | )
(Benefit) provision for income taxes |  | $ | (3,671 | ) |  | $ | 195 |  |  | $ | 218 |
Significant Components of Deferred Tax Assets and Liabilities | The significant components of the Company’s deferred tax assets and liabilities at December 31, 2015 and 2014, were as follows (in thousands):
|  | December 31, |
|  | 2015 |  |  | 2014 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 165,813 |  |  | $ | 151,100 |
Research and development credit carryforwards |  |  | 35,131 |  |  |  | 33,800 |
Capitalized research and development |  |  | 17,916 |  |  |  | 15,500 |
Deferred compensation |  |  | 5,908 |  |  |  | 5,800 |
Capital loss carryforwards |  |  | — |  |  |  | 3,700 |
Other |  |  | 3,911 |  |  |  | 3,200 |
Total deferred tax assets |  |  | 228,679 |  |  |  | 213,100 |
Valuation allowance |  |  | (224,854 | ) |  |  | (213,100 | )
Net deferred tax assets |  |  | 3,825 |  |  |  | — |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Unrealized gain on investments |  |  | 3,825 |  |  |  | — |
Amortization of goodwill |  |  | 122 |  |  |  | 115 |
Total deferred tax liabilities |  | $ | 3,947 |  |  | $ | 115 |

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319 + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 + Details
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- Definition Tabular disclosure of income before income tax between domestic and foreign jurisdictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)(1)(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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