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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2015
Computation of Basic and Diluted Net Loss per Share | The following table sets forth the reconciliation of the numerator and denominator used in the computation of basic and diluted net loss per share for the years ended December 31, 2015, 2014 and 2013 (in thousands, except per share amounts):
|  | Year Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Numerator for Basic and Diluted: |  |  |  |  |  |  |  |  |  |  |  |
Net loss used for basic calculation |  | $ | (55,868 | ) |  | $ | (38,755 | ) |  | $ | (43,337 | )
Effect of revaluation of warrant liability |  |  | (3,566 | ) |  |  | (7,708 | ) |  |  | — |
Adjusted net loss used for dilution calculation |  | $ | (59,434 | ) |  | $ | (46,463 | ) |  | $ | (43,337 | )
Denominator: |  |  |  |  |  |  |  |  |  |  |  |
Basic weighted average number of shares outstanding |  |  | 96,068 |  |  |  | 74,767 |  |  |  | 67,569 |
Effect of dilutive potential shares |  |  | 837 |  |  |  | 1,767 |  |  |  | — |
Diluted weighted average number of shares outstanding |  |  | 96,905 |  |  |  | 76,534 |  |  |  | 67,569 |
Net loss per share: |  |  |  |  |  |  |  |  |  |  |  |
Basic |  | $ | (0.58 | ) |  | $ | (0.52 | ) |  | $ | (0.64 | )
Diluted |  | $ | (0.61 | ) |  | $ | (0.61 | ) |  | $ | (0.64 | )
Anti-Dilutive Effect of Common Shares | The table below presents shares underlying stock options, employee stock purchase plan rights, warrants, restricted stock units and/or convertible preferred stock that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These were excluded from the calculation due to their anti-dilutive effect for the years ended December 31, 2015, 2014 and 2013 (shares in thousands):
|  | Year Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Weighted average number of anti-dilutive potential shares |  |  |  |  |  |  |  |  |  |  |  |
Outstanding options |  |  | 13,681 |  |  |  | 11,722 |  |  |  | 10,296 |
Warrants |  |  | — |  |  |  | — |  |  |  | 6,074 |
Total |  |  | 13,681 |  |  |  | 11,722 |  |  |  | 16,370 |

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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 + Details
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- Definition Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 + Details
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