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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Operating activities |  |  |
Net loss | $ (55,868) | $ (38,755) | $ (43,337)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,699 | 1,415 | 745
Stock-based compensation | 6,730 | 5,153 | 3,268
Changes in valuation of warrant liability | (3,566) | (7,708) | 15,099
Non-cash interest expense (income) | 508 | 131 | (25)
Non-cash deferred manufacturing and development expense | 434 |  |
Deferred income taxes | 7 | 26 | 27
Loss on disposal of fixed assets |  | 3 | 56
Tax benefit from other unrealized gain on available-for-sale securities | (3,825) |  |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (301) | 632 | (1,681)
Inventories | 3,991 | 3,033 | (1,813)
Other assets | 1,379 | (1,655) | 286
Accounts payable | (3,866) | (973) | (1,512)
Accrued liabilities | 1,359 | (1,382) | 2,121
Deferred revenue | 190 | 269 | 104
Net cash used in operating activities | (51,129) | (39,811) | (26,662)
Investing activities |  |  |
Capital expenditures | (722) | (2,106) | (663)
Purchases of investments | (90,407) | (25,981) | (30,146)
Proceeds from maturities of investments | 92,645 | 24,915 | 1,631
Restricted cash | (104) | (175) | (14)
Net cash provided by (used in) investing activities | 1,412 | (3,347) | (29,192)
Financing activities |  |  |
Net proceeds from exercise/purchase of equity incentives and warrants | 12,767 | 11,592 | 1,684
Net proceeds from public offering | 75,300 | 18,488 | 61,425
Proceeds from debt, net of discount | 10,000 | 9,848 | 3,102
Repayment of debt | (113) | (3,474) | (7,568)
Net cash provided by financing activities | 97,954 | 36,454 | 58,643
Net increase (decrease) in cash and cash equivalents | 48,237 | (6,704) | 2,789
Cash and cash equivalents, beginning of year | 22,781 | 29,485 | 26,696
Cash and cash equivalents, end of year | 71,018 | 22,781 | 29,485
Supplemental disclosures: |  |  |
Cash paid for interest | 1,087 | 563 | 294
Cash paid for income taxes | 153 | $ 177 | 146
Non-cash settlement of warranty claim |  |  | $ 1,272
Unpaid manufacturing and development obligation | $ 7,051 |  |

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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=49167202&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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