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Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2015 | Dec. 31, 2014
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 165,813 | $ 151,100
Research and development credit carryforwards | 35,131 | 33,800
Capitalized research and development | 17,916 | 15,500
Deferred compensation | 5,908 | 5,800
Capital loss carryforwards |  | 3,700
Other | 3,911 | 3,200
Total deferred tax assets | 228,679 | 213,100
Valuation allowance | (224,854) | (213,100)
Net deferred tax assets | 3,825 |
Deferred tax liabilities: |  |
Unrealized gain on investments | 3,825 |
Amortization of goodwill | 122 | 115
Total deferred tax liabilities | $ 3,947 | $ 115

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