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v3.4.0.3

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2016 | Mar. 31, 2015
Operating activities |  |
Net loss | $ (16,863) | $ (9,460)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 476 | 443
Stock-based compensation | 1,776 | 1,474
Changes in valuation of warrant liability |  | (6,296)
Non-cash interest expense | 300 | 64
Deferred income taxes | 9 | 1
Non-cash tax expense from other unrealized loss on available-for-sale securities | 768 |
Changes in operating assets and liabilities: |  |
Accounts receivable | 1,708 | 340
Inventories | (488) | (1,220)
Other assets | (213) | (116)
Accounts payable | 995 | 484
Accrued liabilities | (639) | (1,488)
Manufacturing and development obligations | (924) |
Deferred revenue | 52 | 23
Net cash used in operating activities | (13,043) | (15,751)
Investing activities |  |
Capital expenditures | (43) | (59)
Purchases of investments | (50,544) | (69,982)
Proceeds from maturities of investments | 5,500 | 4,400
Restricted cash | 38 | 47
Net cash used in investing activities | (45,049) | (65,594)
Financing activities |  |
Net proceeds from the issuance of common stock in connection with equity incentive plans | 698 | 999
Net proceeds from public offering | 7,199 | 75,527
Repayment of debt | (32) | (28)
Net cash provided by financing activities | 7,865 | 76,498
Net decrease in cash and cash equivalents | (50,227) | (4,847)
Cash and cash equivalents, beginning of year | 71,018 | 22,781
Cash and cash equivalents, end of year | $ 20,791 | $ 17,934

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