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Development and License Agreements - Additional Information (Detail) $ in Thousands, € in Millions | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Mar. 31, 2016 USD ($) | Mar. 31, 2016 EUR (€) | Mar. 31, 2015 USD ($) | Dec. 31, 2016 EUR (€) | Mar. 31, 2016 USD ($) | Mar. 31, 2016 EUR (€) | Dec. 31, 2015 USD ($) | Dec. 31, 2015 EUR (€)
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Manufacturing and development obligations-current | $ 2,219 |  |  |  | $ 2,219 |  | $ 3,282 |
Manufacturing and development obligations-non-current | 4,840 |  |  |  | 4,840 |  | 4,542 |
Payments made relating to the manufacturing of the products | 3,600 |  | $ 4,700 |  |  |  |  |
Amounts due from Fresenius | 900 |  |  |  | 900 |  | 200 |
Other current assets |  |  |  |  |  |  |  |
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Research and development assets | 3,700 |  |  |  | 3,700 |  | 4,100 |
Other assets |  |  |  |  |  |  |  |
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Manufacturing efficiency assets | 2,300 |  |  |  | 2,300 |  | 2,400 |
Fresenius |  |  |  |  |  |  |  |
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Allocated amount for research and development activities | 4,800 |  |  |  | 4,800 |  |  |
Manufacturing efficiency activity cost | 2,400 |  |  |  | 2,400 |  |  |
Manufacturing and Supply Agreement |  |  |  |  |  |  |  |
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Accrual for manufacturing of entity products | 3,200 |  |  |  | 3,200 |  | 2,500 |
Manufacturing and Supply Agreement | Fresenius |  |  |  |  |  |  |  |
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Accrual for manufacturing and development of entity products | 7,000 |  |  |  | $ 7,000 | € 6.2 | 7,800 | € 7.2
Manufacturing and development obligations, discount rate |  |  |  |  | 9.72% |  |  |
Manufacturing and development obligations-current | 2,200 |  |  |  | $ 2,200 | 1.9 | 3,300 | 3.0
Manufacturing and development obligations-non-current | 4,800 |  |  |  | $ 4,800 | € 4.3 | $ 4,500 | € 4.2
Manufacturing and development payments | $ 1,200 | € 1.1 |  |  |  |  |  |
Scenario Forecast | Manufacturing and Supply Agreement | Fresenius |  |  |  |  |  |  |  |
Licenses Agreements [Line Items] |  |  |  |  |  |  |  |
Payments made based on the successful achievement of production volumes | € |  |  |  | € 8.6 |  |  |  |

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