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Development and License Agreements - Additional Information (Detail)
$ in Thousands, € in Millions
3 Months Ended 12 Months Ended
Mar. 31, 2016
USD ($)
Mar. 31, 2016
EUR (€)
Mar. 31, 2015
USD ($)
Dec. 31, 2016
EUR (€)
Mar. 31, 2016
USD ($)
Mar. 31, 2016
EUR (€)
Dec. 31, 2015
USD ($)
Dec. 31, 2015
EUR (€)
Licenses Agreements [Line Items]                
Manufacturing and development obligations-current $ 2,219       $ 2,219   $ 3,282  
Manufacturing and development obligations-non-current 4,840       4,840   4,542  
Payments made relating to the manufacturing of the products 3,600   $ 4,700          
Amounts due from Fresenius 900       900   200  
Other current assets                
Licenses Agreements [Line Items]                
Research and development assets 3,700       3,700   4,100  
Other assets                
Licenses Agreements [Line Items]                
Manufacturing efficiency assets 2,300       2,300   2,400  
Fresenius                
Licenses Agreements [Line Items]                
Allocated amount for research and development activities 4,800       4,800      
Manufacturing efficiency activity cost 2,400       2,400      
Manufacturing and Supply Agreement                
Licenses Agreements [Line Items]                
Accrual for manufacturing of entity products 3,200       3,200   2,500  
Manufacturing and Supply Agreement | Fresenius                
Licenses Agreements [Line Items]                
Accrual for manufacturing and development of entity products 7,000       $ 7,000 € 6.2 7,800 € 7.2
Manufacturing and development obligations, discount rate         9.72%      
Manufacturing and development obligations-current 2,200       $ 2,200 1.9 3,300 3.0
Manufacturing and development obligations-non-current 4,800       $ 4,800 € 4.3 $ 4,500 € 4.2
Manufacturing and development payments $ 1,200 € 1.1            
Scenario Forecast | Manufacturing and Supply Agreement | Fresenius                
Licenses Agreements [Line Items]                
Payments made based on the successful achievement of production volumes | €       € 8.6