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v3.5.0.2

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2016 | Jun. 30, 2015
Operating activities |  |
Net loss | $ (35,029) | $ (25,432)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 964 | 835
Stock-based compensation | 3,862 | 3,179
Changes in valuation of warrant liability |  | (3,589)
Non-cash interest expense | 603 | 139
Deferred income taxes | 18 | 7
Non-cash tax expense (benefit) from other unrealized loss on available-for-sale securities | 1,702 | (2,085)
Changes in operating assets and liabilities: |  |
Accounts receivable | 645 | 69
Inventories | (1,318) | 1,112
Other assets | 435 | 739
Accounts payable | 1,902 | (4,176)
Accrued liabilities | (458) | (1,538)
Manufacturing and development obligations | (1,082) |
Deferred revenue | 189 | 256
Net cash used in operating activities | (27,567) | (30,484)
Investing activities |  |
Capital expenditures | (118) | (325)
Purchases of investments | (70,560) | (69,983)
Proceeds from maturities of investments | 19,500 | 22,444
Restricted cash | 37 | (114)
Net cash used in investing activities | (51,141) | (47,978)
Financing activities |  |
Net proceeds from equity incentives and warrants | 907 | 5,472
Net proceeds from public offering | 14,547 | 75,324
Proceeds from loans |  | 10,000
Repayment of debt | (60) | (56)
Net cash provided by financing activities | 15,394 | 90,740
Net (decrease) increase in cash and cash equivalents | (63,314) | 12,278
Cash and cash equivalents, beginning of period | 71,018 | 22,781
Cash and cash equivalents, end of period | $ 7,704 | $ 35,059

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