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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2016 | Sep. 30, 2015
Operating activities |  |
Net loss | $ (49,405) | $ (41,112)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,394 | 1,229
Stock-based compensation | 5,966 | 4,912
Changes in valuation of warrant liability |  | (4,698)
Non-cash interest expense | 820 | 230
Deferred income taxes | 18 | 12
Non-cash tax expense (benefit) from other unrealized loss on available-for-sale securities | 1,246 | (2,034)
Changes in operating assets and liabilities: |  |
Accounts receivable | (1,647) | (153)
Inventories | (1,432) | 1,970
Other assets | 354 | 802
Accounts payable | 1,562 | (3,085)
Accrued liabilities | 258 | (375)
Manufacturing and development obligations | (3,258) |
Deferred product revenue | 306 | (42)
Net cash used in operating activities | (43,818) | (42,344)
Investing activities |  |
Capital expenditures | (359) | (561)
Purchases of investments | (71,760) | (78,261)
Proceeds from maturities of investments | 33,500 | 57,444
Restricted cash | 34 | (115)
Net cash used in investing activities | (38,585) | (21,493)
Financing activities |  |
Net proceeds from equity incentives and warrants | 2,710 | 6,609
Net proceeds from public offering | 22,146 | 75,327
Proceeds from loans |  | 10,000
Repayment of debt | (591) | (85)
Net cash provided by financing activities | 24,265 | 91,851
Net (decrease) increase in cash and cash equivalents | (58,138) | 28,014
Cash and cash equivalents, beginning of period | 71,018 | 22,781
Cash and cash equivalents, end of period | $ 12,880 | $ 50,795

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