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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2013 |  | 71,859 |  |  |
Balance at Dec. 31, 2013 | $ 42,795 | $ 72 | $ 545,905 | $ 7 | $ (503,189)
Net loss | (38,755) |  |  |  | (38,755)
Other comprehensive income (loss) | (38) |  |  | (38) |
Issuance of common stock from public offering, net of offering costs (in shares) |  | 4,341 |  |  |
Issuance of common stock from public offering, net of offering costs | 18,521 | $ 4 | 18,517 |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares) |  | 4,204 |  |  |
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP | 13,845 | $ 4 | 13,841 |  |
Stock-based compensation | 5,153 |  | 5,153 |  |
Balance (in shares) at Dec. 31, 2014 |  | 80,404 |  |  |
Balance at Dec. 31, 2014 | 41,521 | $ 80 | 583,416 | (31) | (541,944)
Net loss | (55,868) |  |  |  | (55,868)
Other comprehensive income (loss) | 7,320 |  |  | 7,320 |
Issuance of common stock from public offering, net of offering costs (in shares) |  | 14,636 |  |  |
Issuance of common stock from public offering, net of offering costs | 75,376 | $ 15 | 75,361 |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares) |  | 4,055 |  |  |
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP | 19,686 | $ 4 | 19,682 |  |
Stock-based compensation | 6,730 |  | 6,730 |  |
Balance (in shares) at Dec. 31, 2015 |  | 99,095 |  |  |
Balance at Dec. 31, 2015 | 94,765 | $ 99 | 685,189 | 7,289 | (597,812)
Net loss | (62,906) |  |  |  | (62,906)
Other comprehensive income (loss) | (7,186) |  |  | (7,186) |
Issuance of common stock from public offering, net of offering costs (in shares) |  | 3,526 |  |  |
Issuance of common stock from public offering, net of offering costs | 21,981 | $ 3 | 21,978 |  |
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares) |  | 854 |  |  |
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP | 3,068 | $ 1 | 3,067 |  |
Stock-based compensation | 8,065 |  | 8,065 |  |
Balance (in shares) at Dec. 31, 2016 |  | 103,475 |  |  |
Balance at Dec. 31, 2016 | $ 57,787 | $ 103 | $ 718,299 | $ 103 | $ (660,718)

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