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Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 176,490 | $ 165,813
Research and development credit carryforwards | 31,777 | 35,131
Capitalized research and development | 22,575 | 17,916
Deferred compensation | 8,242 | 5,908
Other | 3,184 | 3,911
Total deferred tax assets | 242,268 | 228,679
Valuation allowance | (238,443) | (224,854)
Net deferred tax assets | 3,825 | 3,825
Deferred tax liabilities: |  |
Unrealized gain on investments | 3,825 | 3,825
Amortization of goodwill | 150 | 122
Total deferred tax liabilities | $ 3,975 | $ 3,947

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