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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Operating activities    
Net loss $ (35,681) $ (35,029)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 904 964
Stock-based compensation 4,617 3,862
Bad debt expense 658  
Non-cash interest expense 285 603
Deferred income taxes 12 18
Non-cash tax expense from other unrealized loss on available-for-sale securities 3,825 1,702
Gain on sale of investment in marketable equity securities (3,466)  
Changes in operating assets and liabilities:    
Accounts receivable (1,722) 645
Inventories 237 (1,318)
Other assets 704 435
Accounts payable 1,085 1,902
Accrued liabilities (1,457) (458)
Manufacturing and development obligations 419 (1,082)
Deferred product revenue 233 189
Net cash used in operating activities (29,347) (27,567)
Investing activities    
Capital expenditures (353) (118)
Purchases of investments (20,749) (70,560)
Proceeds from maturities and sale of investments 38,465 19,500
Net cash provided by (used in) investing activities 17,363 (51,178)
Financing activities    
Net proceeds from equity incentives 2,052 907
Net proceeds from public offering 9,644 14,547
Repayment of debt (1,930) (60)
Net cash provided by financing activities 9,766 15,394
Net decrease in cash, cash equivalents and restricted cash (2,218) (63,351)
Cash, cash equivalents and restricted cash, beginning of period 22,744 71,630
Cash, cash equivalents and restricted cash, end of period $ 20,526 $ 8,279