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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2017 | Sep. 30, 2016
Operating activities |  |
Net loss | $ (49,099) | $ (49,405)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,359 | 1,394
Stock-based compensation | 7,008 | 5,966
Non-cash interest expense | 282 | 820
Deferred income taxes | 19 | 18
Non-cash tax expense from other unrealized loss on available-for-sale securities | 3,825 | 1,246
Gain on sale of investment in marketable equity securities | (3,466) |
Changes in operating assets and liabilities: |  |
Accounts receivable | (3,608) | (1,647)
Inventories | (1,800) | (1,432)
Other assets | (379) | 354
Accounts payable | 4,022 | 1,562
Accrued liabilities and other non-current liabilities | (1,477) | 258
Manufacturing and development obligations | 600 | (3,258)
Deferred product revenue | 514 | 306
Net cash used in operating activities | (42,200) | (43,818)
Investing activities |  |
Capital expenditures | (354) | (359)
Purchases of investments | (50,183) | (71,760)
Proceeds from maturities and sale of investments | 55,566 | 33,500
Net cash provided by (used in) investing activities | 5,029 | (38,619)
Financing activities |  |
Net proceeds from equity incentives | 2,421 | 2,710
Net proceeds from public offering | 18,840 | 22,146
Proceeds from loans | 30,000 |
Repayment of debt | (19,593) | (591)
Net cash provided by financing activities | 31,668 | 24,265
Net decrease in cash, cash equivalents and restricted cash | (5,503) | (58,172)
Cash, cash equivalents and restricted cash, beginning of period | 22,744 | 71,630
Cash, cash equivalents and restricted cash, end of period | $ 17,241 | $ 13,458

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