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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Statement [Abstract] |  |  |
Product revenue | $ 43,568,000 | $ 37,183,000 | $ 34,223,000
Cost of product revenue | 22,531,000 | 20,295,000 | 23,464,000
Gross profit on product revenue | 21,037,000 | 16,888,000 | 10,759,000
Government contract revenue | 7,758,000 | 2,092,000 |
Operating expenses: |  |  |
Research and development | 33,710,000 | 31,322,000 | 25,643,000
Selling, general and administrative | 52,413,000 | 48,753,000 | 45,989,000
Amortization of intangible assets | 202,000 | 202,000 | 202,000
Impairment of long-lived assets | 0 | 150,000 | 0
Total operating expenses | 86,325,000 | 80,427,000 | 71,834,000
Loss from operations | (57,530,000) | (61,447,000) | (61,075,000)
Non-operating income (expense), net: |  |  |
Gain from revaluation of warrant liability |  |  | 3,566,000
Foreign exchange (loss) gain | (10,000) | 21,000 | (396,000)
Interest expense | (3,022,000) | (2,445,000) | (1,705,000)
Other income, net | 3,864,000 | 1,140,000 | 71,000
Total non-operating income (expense) , net | 832,000 | (1,284,000) | 1,536,000
Loss before income taxes | (56,698,000) | (62,731,000) | (59,539,000)
Provision (benefit) for income taxes | 3,887,000 | 175,000 | (3,671,000)
Net loss | $ (60,585,000) | $ (62,906,000) | $ (55,868,000)
Net loss per share: |  |  |
Basic | $ (0.56) | $ (0.62) | $ (0.58)
Diluted | $ (0.56) | $ (0.62) | $ (0.61)
Weighted average shares outstanding used for calculating net loss per share: |  |  |
Basic | 108,221 | 101,826 | 96,068
Diluted | 108,221 | 101,826 | 96,905

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