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Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 117,028 | $ 176,490
Research and development credit carryforwards | 25,061 | 22,128
Capitalized research and development | 17,195 | 22,575
Deferred compensation | 7,011 | 8,242
Other | 3,116 | 3,184
Total deferred tax assets | 169,411 | 232,619
Valuation allowance | (169,332) | (228,794)
Net deferred tax assets | 79 | 3,825
Deferred tax liabilities: |  |
Unrealized gain on investments |  | 3,825
Amortization of goodwill | 111 | 150
Total deferred tax liabilities | $ 111 | $ 3,975

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