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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2017

Accounting Policies [Abstract]

Computation of Basic and Diluted Net Loss per Share

The following table sets forth the reconciliation of the numerator and denominator used in the computation of basic and diluted net loss per share for the years ended December 31, 2017, 2016 and 2015 (in thousands, except per share amounts):

		Year Ended December 31,
		2017				2016				2015
Numerator for Basic and Diluted:
Net loss used for basic calculation		$	(60,585	)		$	(62,906	)		$	(55,868	)
Effect of revaluation of warrant liability			—				—				(3,566	)
Adjusted net loss used for dilution calculation		$	(60,585	)		$	(62,906	)		$	(59,434	)
Denominator:
Basic weighted average number of shares outstanding			108,221				101,826				96,068
Effect of dilutive potential shares			—				—				837
Diluted weighted average number of shares outstanding			108,221				101,826				96,905
Net loss per share:
Basic		$	(0.56	)		$	(0.62	)		$	(0.58	)
Diluted			(0.56	)			(0.62	)			(0.61	)

Anti-Dilutive Effect of Common Shares

The table below presents shares underlying stock options, restricted stock units, and employee stock purchase plan rights that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These are excluded from the calculation due to their anti-dilutive effect for the years ended December 31, 2017, 2016 and 2015 (shares in thousands):

		Year Ended December 31,
		2017				2016				2015
Weighted average number of anti-dilutive potential shares:
Stock options			17,373				15,592				13,681
Restricted stock units			1,225				576				—
Employee stock purchase plan rights			21				43				5
Total			18,619				16,211				13,686

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- References

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- Definition

Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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- Definition

Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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