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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

United States and Foreign Components of Consolidated Loss Before Income Taxes

U.S and foreign components of consolidated loss before income taxes for the years ended December 31, 2017, 2016 and 2015, was as follows (in thousands):

		2017				2016				2015
Loss before income taxes:
U.S.		$	(57,925	)		$	(63,246	)		$	(59,897	)
Foreign			1,227				515				358
Loss before income taxes		$	(56,698	)		$	(62,731	)		$	(59,539	)

Provision Benefit for Income Taxes

The provision for income taxes for the years ended December 31, 2017, 2016 and 2015, was as follows (in thousands):

		2017				2016				2015
Provision for income taxes:
Current:
Foreign		$	181			$	147			$	147
Federal			—				—				—
State			—				—				—
Total current			181				147				147
Deferred:
Foreign			—				—				—
Federal			3,659				28				(3,750	)
State			47				—				(68	)
Total deferred			3,706				28				(3,818	)
Provision (benefit)  for income taxes		$	3,887			$	175			$	(3,671	)

Difference Between Provision for Income Taxes and Amounts Computed by Applying Federal Statutory Income Tax Rate to Loss before Taxes

The difference between the provision for income taxes and the amount computed by applying the federal statutory income tax rate to loss before taxes for the years ended December 31, 2017, 2016 and 2015, was as follows (in thousands):

		2017				2016				2015
Federal statutory tax		$	(19,277	)		$	(21,329	)		$	(20,243	)
Tax Act revaluation of deferred taxes			81,923				—				—
Tax Act deemed income inclusion			1,083				—				—
Federal research credits			(1,000	)			(809	)			(838	)
Warrants			—				—				(3,565	)
Expiration of federal loss carryovers			—				—				3,337
Expiration of California loss carryovers			1,475				—				—
Change in valuation allowance			(59,462	)			3,940				11,754
Non-deductible stock based compensation			1,382				484				449
Change in state apportionment			—				—				4,085
Revision to prior year items			—				17,200				—
Other			(2,237	)			689				1,350
Provision (benefit) for income taxes		$	3,887			$	175			$	(3,671	)

Significant Components of Deferred Tax Assets and Liabilities

The significant components of the Company’s deferred tax assets and liabilities at December 31, 2017 and 2016, were as follows (in thousands):

		December 31,
		2017				2016
Deferred tax assets:
Net operating loss carryforwards		$	117,028			$	176,490
Research and development credit carryforwards			25,061				22,128
Capitalized research and development			17,195				22,575
Deferred compensation			7,011				8,242
Other			3,116				3,184
Total deferred tax assets			169,411				232,619
Valuation allowance			(169,332	)			(228,794	)
Net deferred tax assets		$	79			$	3,825
Deferred tax liabilities:
Unrealized gain on investments		$	—			$	3,825
Amortization of goodwill			111				150
Total deferred tax liabilities		$	111			$	3,975

Gross Amounts and Dates of Expiration of Tax Credits and Carryovers

The Company's tax losses and credits are subject to varying carryforward periods. The gross amounts and dates of expiration of the significant carryforwards are as follows:

						Expires				Expires				Expires				No
		Total				2018-2020				2021-2027				2028-2037				Expiration
Federal losses carryovers		$	531,303			$	74,073			$	145,248			$	311,982			$	—
California loss carryovers			73,860				19,243				—				54,617				—
Federal research credits			17,642				3,262				9,866				4,514				—
California research credits			9,391				—				—				—				9,391
Federal foreign tax credits			610				—				610				—				—

Reconciliation of Unrecognized Tax Benefits

The following is a tabular reconciliation of the total amounts of unrecognized tax benefits (in thousands):

		December 31,				December 31,
		2017				2016
Unrecognized tax benefits at beginning of period		$	10,836			$	—
Increases related to prior year tax positions			19				10,691
Increases related to current year tax positions			207				145
Unrecognized tax benefits at end of period		$	11,062			$	10,836

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