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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2014 $ 41,521 $ 80 $ 583,416 $ (31) $ (541,944)
Balance (in shares) at Dec. 31, 2014   80,404      
Net loss (55,868)       (55,868)
Other comprehensive income (loss) 7,320     7,320  
Issuance of common stock from public offering, net of offering costs 75,376 $ 15 75,361    
Issuance of common stock from public offering, net of offering costs (in shares)   14,636      
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP 19,686 $ 4 19,682    
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares)   4,055      
Stock-based compensation 6,730   6,730    
Balance at Dec. 31, 2015 94,765 $ 99 685,189 7,289 (597,812)
Balance (in shares) at Dec. 31, 2015   99,095      
Net loss (62,906)       (62,906)
Other comprehensive income (loss) (7,186)     (7,186)  
Issuance of common stock from public offering, net of offering costs 21,981 $ 3 21,978    
Issuance of common stock from public offering, net of offering costs (in shares)   3,526      
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP 3,068 $ 1 3,067    
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP(In Shares)   854      
Stock-based compensation 8,065   8,065    
Balance at Dec. 31, 2016 57,787 $ 103 718,299 103 (660,718)
Balance (in shares) at Dec. 31, 2016   103,475      
Net loss (60,585)       (60,585)
Other comprehensive income (loss) (200)     (200)  
Issuance of common stock from public offering, net of offering costs 30,156 $ 11 30,145    
Issuance of common stock from public offering, net of offering costs (in shares)   10,986      
Issuance of common stock from exercise of stock options and/or warrants, vesting of restricted stock units, and purchases from ESPP 2,427 $ 1 2,426    
Issuance of common stock from exercise of stock options and/or warrants, vesting of restricted stock units, and purchases from ESPP (In Shares)   1,094      
Stock-based compensation 9,355   9,355    
Balance at Dec. 31, 2017 $ 38,940 $ 115 $ 760,225 $ (97) $ (721,303)
Balance (in shares) at Dec. 31, 2017   115,555